Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
Location | 2267392..2268311 | Replicon | chromosome |
Accession | NZ_LR882499 | ||
Organism | Mycobacterium tuberculosis variant microti OV254 isolate vole |
Toxin (Protein)
Gene name | HigB2 | Uniprot ID | L7N4R2 |
Locus tag | JN986_RS10465 | Protein ID | WP_003900449.1 |
Coordinates | 2267706..2268311 (-) | Length | 202 a.a. |
Antitoxin (Protein)
Gene name | HigA2 | Uniprot ID | L7N5K9 |
Locus tag | JN986_RS10460 | Protein ID | WP_003410124.1 |
Coordinates | 2267392..2267697 (-) | Length | 102 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JN986_RS10430 | 2262403..2263659 | - | 1257 | WP_003410095.1 | HNH endonuclease | - |
JN986_RS10435 | 2264013..2264588 | + | 576 | WP_003410100.1 | hypothetical protein | - |
JN986_RS10440 | 2264585..2265625 | + | 1041 | WP_003410103.1 | ImmA/IrrE family metallo-endopeptidase | - |
JN986_RS10445 | 2265867..2266586 | + | 720 | WP_003410108.1 | DUF433 domain-containing protein | - |
JN986_RS10450 | 2266576..2266992 | + | 417 | WP_003410114.1 | hypothetical protein | - |
JN986_RS10455 | 2267008..2267307 | - | 300 | WP_003410120.1 | hypothetical protein | - |
JN986_RS10460 | 2267392..2267697 | - | 306 | WP_003410124.1 | XRE family transcriptional regulator | Antitoxin |
JN986_RS10465 | 2267706..2268311 | - | 606 | WP_003900449.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
JN986_RS10470 | 2268336..2268695 | - | 360 | WP_003410131.1 | hypothetical protein | - |
JN986_RS10475 | 2268855..2269532 | - | 678 | WP_003900450.1 | hypothetical protein | - |
JN986_RS10480 | 2269484..2269720 | - | 237 | WP_003410133.1 | hypothetical protein | - |
JN986_RS10485 | 2269927..2270823 | - | 897 | WP_003410136.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 202 a.a. Molecular weight: 22744.96 Da Isoelectric Point: 7.3073
>T289877 WP_003900449.1 NZ_LR882499:c2268311-2267706 [Mycobacterium tuberculosis variant microti OV254]
VNVPWENAHGGALYCLIRGDEFSAWHRLLFQRPGCAESVLACRHFLDGSPVARCSYPEEYHPCVISRIALLCDSVGWTAD
VERISAWLNGLDRETYELVFAAIEVLEEEGPALGCPLVDTVRGSRHKNMKELRPGSQGRSEVRILFAFDPARQAIMLAAG
NKAGRWTQWYDEKIKAADEMFAEHLAQFEDTKPKRRKRKKG
VNVPWENAHGGALYCLIRGDEFSAWHRLLFQRPGCAESVLACRHFLDGSPVARCSYPEEYHPCVISRIALLCDSVGWTAD
VERISAWLNGLDRETYELVFAAIEVLEEEGPALGCPLVDTVRGSRHKNMKELRPGSQGRSEVRILFAFDPARQAIMLAAG
NKAGRWTQWYDEKIKAADEMFAEHLAQFEDTKPKRRKRKKG
Download Length: 606 bp
Antitoxin
Download Length: 102 a.a. Molecular weight: 11291.91 Da Isoelectric Point: 10.7482
>AT289877 WP_003410124.1 NZ_LR882499:c2267697-2267392 [Mycobacterium tuberculosis variant microti OV254]
MAMTLRDMDAVRPVNREAVDRHKARMRDEVRAFRLRELRAAQSLTQVQVAALAHIRQSRVSSIENGDIGSAQVNTLRKYV
SALGGELDITVRLGDETFTLA
MAMTLRDMDAVRPVNREAVDRHKARMRDEVRAFRLRELRAAQSLTQVQVAALAHIRQSRVSSIENGDIGSAQVNTLRKYV
SALGGELDITVRLGDETFTLA
Download Length: 306 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4BV20 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4BV30 |