289871

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/Gp49-HTH_37
Location 2213665..2214533 Replicon chromosome
Accession NZ_LR882499
Organism Mycobacterium tuberculosis variant microti OV254 isolate vole

Toxin (Protein)


Gene name higB Uniprot ID P9WJA4
Locus tag JN986_RS10145 Protein ID WP_010886136.1
Coordinates 2213665..2214042 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID G0TLM0
Locus tag JN986_RS10150 Protein ID WP_003409886.1
Coordinates 2214084..2214533 (+) Length 150 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN986_RS10095 2209454..2209906 - 453 WP_003899095.1 lipoprotein -
JN986_RS10100 2209970..2210371 + 402 WP_003409869.1 hypothetical protein -
JN986_RS10105 2210364..2210546 - 183 WP_003409870.1 hypothetical protein -
JN986_RS10110 2210660..2211010 - 351 WP_003409871.1 hypothetical protein -
JN986_RS10115 2211021..2211923 - 903 WP_003409874.1 hypothetical protein -
JN986_RS10120 2211944..2212135 - 192 WP_003409876.1 hypothetical protein -
JN986_RS10125 2212136..2212432 - 297 WP_003409877.1 hypothetical protein -
JN986_RS10130 2212672..2212887 + 216 WP_003409878.1 antitoxin -
JN986_RS10135 2212884..2213195 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
JN986_RS10140 2213169..2213690 - 522 WP_003904745.1 hypothetical protein -
JN986_RS10145 2213665..2214042 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB Toxin
JN986_RS10150 2214084..2214533 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
JN986_RS10155 2214530..2215075 + 546 WP_003409891.1 SecB-like chaperone -
JN986_RS10160 2214964..2215578 - 615 WP_003901296.1 hypothetical protein -
JN986_RS10165 2215627..2215923 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin -
JN986_RS10170 2215920..2216171 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin -
JN986_RS10175 2216158..2216652 + 495 WP_003899099.1 hypothetical protein -
JN986_RS10180 2216812..2217219 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
JN986_RS10185 2217223..2217495 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
JN986_RS10190 2217528..2218748 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(27-113)

Antitoxin

(44-91)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 14397.77 Da        Isoelectric Point: 10.8862

>T289871 WP_010886136.1 NZ_LR882499:2213665-2214042 [Mycobacterium tuberculosis variant microti OV254]
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI

Download         Length: 378 bp


Antitoxin


Download         Length: 150 a.a.        Molecular weight: 16760.16 Da        Isoelectric Point: 8.0771

>AT289871 WP_003409886.1 NZ_LR882499:2214084-2214533 [Mycobacterium tuberculosis variant microti OV254]
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA

Download         Length: 450 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 7AWK
PDB 7NBU


Antitoxin

Source ID Structure
AlphaFold DB G0TLM0

References