Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 847476..848076 Replicon chromosome
Accession NC_020453
Organism Bradyrhizobium oligotrophicum S58

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag S58_RS03830 Protein ID WP_042338677.1
Coordinates 847792..848076 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag S58_RS03825 Protein ID WP_015663922.1
Coordinates 847476..847781 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
S58_RS03805 842921..843388 + 468 WP_015663919.1 secondary thiamine-phosphate synthase enzyme YjbQ -
S58_RS03810 843497..845167 - 1671 WP_173424414.1 MHS family MFS transporter -
S58_RS03815 845522..846196 + 675 WP_042340526.1 response regulator transcription factor -
S58_RS03825 847476..847781 - 306 WP_015663922.1 HigA family addiction module antidote protein Antitoxin
S58_RS03830 847792..848076 - 285 WP_042338677.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
S58_RS03835 848323..848874 - 552 WP_015663924.1 peroxidase-related enzyme -
S58_RS03840 848969..849769 + 801 WP_015663925.1 AraC family transcriptional regulator -
S58_RS03845 849792..850169 - 378 WP_015663926.1 hypothetical protein -
S58_RS03850 850322..851134 - 813 WP_015663927.1 alpha/beta hydrolase -
S58_RS03855 851175..852146 - 972 WP_015663928.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-94)

Antitoxin

Cro/C1-type helix-turn-helix domain

(9-66)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10703.08 Da        Isoelectric Point: 9.0175

>T28983 WP_042338677.1 NC_020453:c848076-847792 [Bradyrhizobium oligotrophicum S58]
MIVGYRDRRTERFANGEVVREFSGFARQAGIRLDRLEAATSLKDLGALPGNRLEALKGNRQGQYSIRINDQWRICFEWPP
GSPGPVNVEIVDYH

Download         Length: 285 bp

>T28983 NC_020453:c848076-847792 [Bradyrhizobium oligotrophicum S58]
ATGATCGTCGGCTACCGGGACAGGAGAACCGAGCGCTTTGCAAATGGCGAAGTCGTCAGGGAATTCTCTGGTTTCGCCCG
CCAGGCGGGAATTCGGCTCGACCGACTGGAAGCCGCAACGAGCTTGAAGGATCTCGGCGCCCTGCCCGGAAATCGGCTAG
AGGCGCTCAAGGGCAATCGACAAGGTCAGTACAGCATCCGCATCAACGATCAGTGGCGGATTTGTTTCGAATGGCCGCCC
GGCTCGCCCGGTCCTGTCAACGTCGAGATCGTCGACTATCATTAG

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11168.80 Da        Isoelectric Point: 7.3196

>AT28983 WP_015663922.1 NC_020453:c847781-847476 [Bradyrhizobium oligotrophicum S58]
MARSPIHPGVQLAEELDELGMSAAELARQLDVPVNRITAIINGQRSITADTALRLGHWFGTSPDFWLNLQKIYELRLAQQ
EIGDAVKKLPTRAARLGTAHQ

Download         Length: 306 bp

>AT28983 NC_020453:c847781-847476 [Bradyrhizobium oligotrophicum S58]
ATGGCACGCAGTCCCATTCACCCGGGCGTTCAACTCGCCGAAGAGCTCGATGAGCTCGGGATGTCGGCGGCAGAGCTGGC
GCGCCAGCTCGACGTGCCCGTCAACAGGATCACCGCGATCATCAACGGCCAGCGCAGCATCACCGCCGATACGGCGCTGC
GCCTCGGTCACTGGTTTGGGACGAGCCCTGATTTCTGGCTCAACCTGCAAAAGATCTATGAGCTGCGGCTAGCTCAGCAG
GAGATTGGCGACGCCGTGAAGAAACTGCCGACACGTGCAGCCCGGTTAGGCACAGCGCATCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References