289811

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Gp49-HTH_37
Location 2216585..2217453 Replicon chromosome
Accession NZ_LR882498
Organism Mycobacterium tuberculosis variant microti strain Maus III isolate human

Toxin (Protein)


Gene name higB Uniprot ID P9WJA4
Locus tag JN980_RS10170 Protein ID WP_010886136.1
Coordinates 2216585..2216962 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID G0TLM0
Locus tag JN980_RS10175 Protein ID WP_003409886.1
Coordinates 2217004..2217453 (+) Length 150 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN980_RS10120 2212374..2212826 - 453 WP_003899095.1 lipoprotein -
JN980_RS10125 2212890..2213291 + 402 WP_003409869.1 hypothetical protein -
JN980_RS10130 2213284..2213466 - 183 WP_003409870.1 hypothetical protein -
JN980_RS10135 2213580..2213930 - 351 WP_003409871.1 hypothetical protein -
JN980_RS10140 2213941..2214843 - 903 WP_003409874.1 hypothetical protein -
JN980_RS10145 2214864..2215055 - 192 WP_003409876.1 hypothetical protein -
JN980_RS10150 2215056..2215352 - 297 WP_003409877.1 hypothetical protein -
JN980_RS10155 2215592..2215807 + 216 WP_003409878.1 antitoxin -
JN980_RS10160 2215804..2216115 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
JN980_RS10165 2216089..2216610 - 522 WP_003904745.1 hypothetical protein -
JN980_RS10170 2216585..2216962 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB Toxin
JN980_RS10175 2217004..2217453 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
JN980_RS10180 2217450..2217995 + 546 WP_003409891.1 SecB-like chaperone -
JN980_RS10185 2217884..2218498 - 615 WP_003901296.1 hypothetical protein -
JN980_RS10190 2218547..2218843 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin -
JN980_RS10195 2218840..2219091 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin -
JN980_RS10200 2219078..2219572 + 495 WP_003899099.1 hypothetical protein -
JN980_RS10205 2219732..2220139 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
JN980_RS10210 2220143..2220415 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
JN980_RS10215 2220448..2221668 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(27-113)

Antitoxin

Cro/C1-type helix-turn-helix domain

(44-91)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14397.77 Da        Isoelectric Point: 10.8862

>T289811 WP_010886136.1 NZ_LR882498:2216585-2216962 [Mycobacterium tuberculosis variant microti]
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI

Download         Length: 378 bp

Antitoxin


Download         Length: 150 a.a.        Molecular weight: 16760.16 Da        Isoelectric Point: 8.0771

>AT289811 WP_003409886.1 NZ_LR882498:2217004-2217453 [Mycobacterium tuberculosis variant microti]
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA

Download         Length: 450 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AWK
PDB 7NBU

Antitoxin

Source ID Structure
AlphaFold DB G0TLM0

References