289715

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3540821..3541491 Replicon chromosome
Accession NZ_LR882496
Organism Mycobacterium tuberculosis variant microti strain ATCC 35782 isolate vole

Toxin (Protein)


Gene name higB Uniprot ID O53332
Locus tag JN993_RS16520 Protein ID WP_003899954.1
Coordinates 3540821..3541165 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID G0THF6
Locus tag JN993_RS16525 Protein ID WP_003899955.1
Coordinates 3541162..3541491 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN993_RS16490 3535894..3536754 + 861 WP_202589904.1 alpha/beta hydrolase -
JN993_RS16495 3536729..3537244 + 516 WP_003899950.1 nitroreductase family deazaflavin-dependent oxidoreductase -
JN993_RS16500 3537484..3537777 + 294 WP_003416635.1 hypothetical protein -
JN993_RS16505 3538065..3539354 + 1290 WP_003416640.1 ATP-binding protein -
JN993_RS16510 3539701..3540135 - 435 WP_003899952.1 type II toxin-antitoxin system VapC family toxin -
JN993_RS16515 3540138..3540590 - 453 WP_003899953.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
JN993_RS16520 3540821..3541165 + 345 WP_003899954.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JN993_RS16525 3541162..3541491 + 330 WP_003899955.1 XRE family transcriptional regulator Antitoxin
JN993_RS16530 3541853..3543114 + 1262 WP_105799563.1 IS3-like element IS987 family transposase -
JN993_RS16535 3543387..3543734 + 348 WP_003899956.1 DUF2384 domain-containing protein -
JN993_RS16540 3543731..3544351 + 621 WP_003899957.1 RES family NAD+ phosphorylase -
JN993_RS16545 3544511..3545776 - 1266 WP_003909837.1 hypothetical protein -
JN993_RS16550 3545944..3546153 + 210 WP_003416778.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-91)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12692.50 Da        Isoelectric Point: 5.6920

>T289715 WP_003899954.1 NZ_LR882496:3540821-3541165 [Mycobacterium tuberculosis variant microti]
MAVILLPQVERWFFALNRDAMASVTGAIDLLEMEGPTLGRPVVDKVNDSTFHNMKELRPAGTSIRILFAFDPARQAILLL
GGDKAGNWKRWYDNNIPIADQRSENWLASEHGGG

Download         Length: 345 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11802.46 Da        Isoelectric Point: 7.4051

>AT289715 WP_003899955.1 NZ_LR882496:3541162-3541491 [Mycobacterium tuberculosis variant microti]
MTMARNWRDIRADAVAQGRVDLQRAAVAREEMRDAVLAHRLAEIRKALGHARQADVAALMGVSQARVSKLESGDLSHTEL
GTLQAYVAALGGHLRIVAEFGENTVELTA

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBK2

Antitoxin

Source ID Structure
AlphaFold DB G0THF6

References