289691

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Gp49-HTH_37
Location 2206758..2207626 Replicon chromosome
Accession NZ_LR882496
Organism Mycobacterium tuberculosis variant microti strain ATCC 35782 isolate vole

Toxin (Protein)


Gene name higB Uniprot ID P9WJA4
Locus tag JN993_RS10140 Protein ID WP_010886136.1
Coordinates 2206758..2207135 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID G0TLM0
Locus tag JN993_RS10145 Protein ID WP_003409886.1
Coordinates 2207177..2207626 (+) Length 150 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN993_RS10090 2202547..2202999 - 453 WP_003899095.1 lipoprotein -
JN993_RS10095 2203063..2203464 + 402 WP_003409869.1 hypothetical protein -
JN993_RS10100 2203457..2203639 - 183 WP_003409870.1 hypothetical protein -
JN993_RS10105 2203753..2204103 - 351 WP_003409871.1 hypothetical protein -
JN993_RS10110 2204114..2205016 - 903 WP_003409874.1 hypothetical protein -
JN993_RS10115 2205037..2205228 - 192 WP_003409876.1 hypothetical protein -
JN993_RS10120 2205229..2205525 - 297 WP_003409877.1 hypothetical protein -
JN993_RS10125 2205765..2205980 + 216 WP_003409878.1 antitoxin -
JN993_RS10130 2205977..2206288 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
JN993_RS10135 2206262..2206783 - 522 WP_162298263.1 hypothetical protein -
JN993_RS10140 2206758..2207135 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB Toxin
JN993_RS10145 2207177..2207626 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
JN993_RS10150 2207623..2208168 + 546 WP_003409891.1 SecB-like chaperone -
JN993_RS10155 2208057..2208671 - 615 WP_003901296.1 hypothetical protein -
JN993_RS10160 2208720..2209016 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin -
JN993_RS10165 2209013..2209264 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin -
JN993_RS10170 2209251..2209745 + 495 WP_003899099.1 hypothetical protein -
JN993_RS10175 2209905..2210312 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
JN993_RS10180 2210316..2210588 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
JN993_RS10185 2210621..2211841 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(27-113)

Antitoxin

Cro/C1-type helix-turn-helix domain

(44-91)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14397.77 Da        Isoelectric Point: 10.8862

>T289691 WP_010886136.1 NZ_LR882496:2206758-2207135 [Mycobacterium tuberculosis variant microti]
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI

Download         Length: 378 bp

Antitoxin


Download         Length: 150 a.a.        Molecular weight: 16760.16 Da        Isoelectric Point: 8.0771

>AT289691 WP_003409886.1 NZ_LR882496:2207177-2207626 [Mycobacterium tuberculosis variant microti]
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA

Download         Length: 450 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AWK
PDB 7NBU

Antitoxin

Source ID Structure
AlphaFold DB G0TLM0

References