Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 24181..24787 Replicon plasmid pSYSM_M
Accession NC_020296
Organism Synechocystis sp. PCC 6803

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag MYO_RS16655 Protein ID WP_011153557.1
Coordinates 24181..24462 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MYO_RS16660 Protein ID WP_011153558.1
Coordinates 24473..24787 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MYO_RS16625 20523..21479 - 957 WP_011153551.1 hypothetical protein -
MYO_RS16630 21479..21760 - 282 WP_011153552.1 hypothetical protein -
MYO_RS16635 21843..23219 + 1377 WP_011153553.1 hypothetical protein -
MYO_RS16640 23255..23572 + 318 WP_011153554.1 nucleotidyltransferase domain-containing protein -
MYO_RS16645 23562..23903 + 342 WP_011153555.1 DUF86 domain-containing protein -
MYO_RS16650 23890..24099 + 210 WP_011153556.1 aminotransferase class V-fold PLP-dependent enzyme -
MYO_RS16655 24181..24462 + 282 WP_011153557.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MYO_RS16660 24473..24787 + 315 WP_011153558.1 HigA family addiction module antidote protein Antitoxin
MYO_RS16665 24798..25955 + 1158 WP_011153559.1 cysteine desulfurase -
MYO_RS16670 25994..27175 + 1182 WP_011153560.1 AAA family ATPase -
MYO_RS16675 27175..27735 + 561 WP_011153561.1 DUF4276 family protein -
MYO_RS16680 27859..28053 - 195 WP_011153562.1 DUF433 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..118712 118712


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-84)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11075.72 Da        Isoelectric Point: 10.3094

>T28967 WP_011153557.1 NC_020296:24181-24462 [Synechocystis sp. PCC 6803]
VIRNFKDKEAQKIFERQRSRKLPGDIQQVALRKLRMLNRAETLQDLKVPPANRLEALKGDRQGQYSIRINAQWRICFQWE
NGEALDVEIIDYH

Download         Length: 282 bp

>T28967 NC_020296:24181-24462 [Synechocystis sp. PCC 6803]
GTGATTCGTAACTTTAAAGATAAAGAAGCTCAAAAAATCTTTGAACGACAACGCTCCCGCAAACTGCCTGGCGACATCCA
ACAAGTTGCCCTCAGAAAGCTCCGAATGCTAAACCGAGCCGAGACATTACAAGACCTTAAAGTTCCCCCAGCTAATCGAT
TAGAAGCTTTGAAAGGCGATCGCCAAGGACAATATAGCATTCGCATTAATGCCCAATGGCGTATCTGTTTCCAATGGGAG
AACGGAGAAGCCCTCGACGTAGAAATTATTGACTACCATTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11963.85 Da        Isoelectric Point: 4.8359

>AT28967 WP_011153558.1 NC_020296:24473-24787 [Synechocystis sp. PCC 6803]
MNPDKLKPIHPGEVLLEEFLQPMNLSQNKLALAIRVPARRINEIVQGKRRITADTALRLALYFNMSPRFWLGLQMDYDLD
LAEDEIGEKLQQEVTTFNLDNVAV

Download         Length: 315 bp

>AT28967 NC_020296:24473-24787 [Synechocystis sp. PCC 6803]
ATGAATCCAGACAAACTAAAACCTATTCATCCCGGCGAAGTTCTCCTTGAAGAATTTTTGCAGCCAATGAATCTAAGCCA
AAATAAGCTAGCTTTAGCAATTCGTGTACCTGCTCGTCGTATCAACGAAATTGTGCAGGGAAAACGTCGTATTACCGCTG
ATACCGCCCTACGTTTAGCACTATATTTCAATATGTCTCCTCGGTTTTGGTTAGGCTTGCAAATGGACTATGACCTAGAT
TTAGCAGAGGATGAAATTGGCGAAAAGCTTCAACAGGAAGTAACGACTTTCAATCTAGACAACGTTGCCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References