289648

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2746600..2747102 Replicon chromosome
Accession NZ_LR882493
Organism Escherichia coli isolate 2016-17-292

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag IHO92_RS13530 Protein ID WP_000767829.1
Coordinates 2746600..2746854 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag IHO92_RS13535 Protein ID WP_001259255.1
Coordinates 2746851..2747102 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHO92_RS13505 2742585..2742914 - 330 Protein_2643 transport protein YeeE -
IHO92_RS13510 2743093..2744451 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
IHO92_RS13515 2744441..2744503 - 63 WP_010723108.1 membrane protein YoeI -
IHO92_RS13520 2744718..2745647 - 930 WP_000803351.1 LysR family transcriptional regulator -
IHO92_RS13525 2745693..2746517 - 825 WP_000754758.1 SDR family oxidoreductase -
IHO92_RS13530 2746600..2746854 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
IHO92_RS13535 2746851..2747102 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
IHO92_RS13540 2747386..2747436 + 51 WP_001364200.1 his operon leader peptide -
IHO92_RS13545 2747582..2748481 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
IHO92_RS13550 2748487..2749791 + 1305 WP_001317939.1 histidinol dehydrogenase -
IHO92_RS13555 2749788..2750858 + 1071 WP_000108941.1 histidinol-phosphate transaminase -
IHO92_RS13560 2750858..2751925 + 1068 WP_000080060.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T289648 WP_000767829.1 NZ_LR882493:c2746854-2746600 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT289648 WP_001259255.1 NZ_LR882493:c2747102-2746851 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References