Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2746600..2747102 Replicon chromosome
Accession NZ_LR882493
Organism Escherichia coli isolate 2016-17-292

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag IHO92_RS13530 Protein ID WP_000767829.1
Coordinates 2746600..2746854 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag IHO92_RS13535 Protein ID WP_001259255.1
Coordinates 2746851..2747102 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHO92_RS13505 2742585..2742914 - 330 Protein_2643 transport protein YeeE -
IHO92_RS13510 2743093..2744451 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
IHO92_RS13515 2744441..2744503 - 63 WP_010723108.1 membrane protein YoeI -
IHO92_RS13520 2744718..2745647 - 930 WP_000803351.1 LysR family transcriptional regulator -
IHO92_RS13525 2745693..2746517 - 825 WP_000754758.1 SDR family oxidoreductase -
IHO92_RS13530 2746600..2746854 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
IHO92_RS13535 2746851..2747102 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
IHO92_RS13540 2747386..2747436 + 51 WP_001364200.1 his operon leader peptide -
IHO92_RS13545 2747582..2748481 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
IHO92_RS13550 2748487..2749791 + 1305 WP_001317939.1 histidinol dehydrogenase -
IHO92_RS13555 2749788..2750858 + 1071 WP_000108941.1 histidinol-phosphate transaminase -
IHO92_RS13560 2750858..2751925 + 1068 WP_000080060.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T289648 WP_000767829.1 NZ_LR882493:c2746854-2746600 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT289648 WP_001259255.1 NZ_LR882493:c2747102-2746851 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References