Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 718576..719269 Replicon chromosome
Accession NZ_LR882493
Organism Escherichia coli isolate 2016-17-292

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag IHO92_RS03500 Protein ID WP_000415584.1
Coordinates 718576..718872 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag IHO92_RS03505 Protein ID WP_000650107.1
Coordinates 718874..719269 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHO92_RS03470 714251..714565 - 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -
IHO92_RS03475 714596..715177 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
IHO92_RS03480 715287..716636 - 1350 WP_000673406.1 two-component system sensor histidine kinase QseC -
IHO92_RS03485 716633..717292 - 660 WP_001221491.1 two-component system response regulator QseB -
IHO92_RS03490 717444..717836 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
IHO92_RS03495 717889..718371 + 483 WP_000183494.1 transcriptional regulator -
IHO92_RS03500 718576..718872 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
IHO92_RS03505 718874..719269 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
IHO92_RS03510 719402..721009 + 1608 WP_001701096.1 ABC transporter substrate-binding protein -
IHO92_RS03515 721147..723405 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 706848..719269 12421


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T289638 WP_000415584.1 NZ_LR882493:718576-718872 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT289638 WP_000650107.1 NZ_LR882493:718874-719269 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References