Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 41580..41834 Replicon plasmid 5
Accession NZ_LR882061
Organism Escherichia coli isolate 2014-01-7375

Toxin (Protein)


Gene name srnB Uniprot ID G9G1E3
Locus tag IHP09_RS25555 Protein ID WP_001312851.1
Coordinates 41685..41834 (+) Length 50 a.a.

Antitoxin (RNA)


Gene name srnC
Locus tag -
Coordinates 41580..41638 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHP09_RS25530 38070..38291 + 222 WP_000412083.1 hypothetical protein -
IHP09_RS25535 38299..39048 + 750 WP_000123038.1 type-F conjugative transfer system pilin acetylase TraX -
IHP09_RS25540 39122..39682 + 561 WP_000139377.1 fertility inhibition protein FinO -
IHP09_RS25545 39836..40030 - 195 WP_001115778.1 hypothetical protein -
IHP09_RS25550 40394..40993 + 600 WP_000256073.1 hypothetical protein -
- 41580..41638 - 59 NuclAT_1 - Antitoxin
- 41580..41638 - 59 NuclAT_1 - Antitoxin
- 41580..41638 - 59 NuclAT_1 - Antitoxin
- 41580..41638 - 59 NuclAT_1 - Antitoxin
IHP09_RS25555 41685..41834 + 150 WP_001312851.1 type I toxin-antitoxin system Hok family toxin Toxin
IHP09_RS25560 42102..42356 + 255 WP_000083830.1 replication regulatory protein RepA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..42660 42660


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(4-45)


Sequences

Toxin        


Download         Length: 50 a.a.        Molecular weight: 5542.67 Da        Isoelectric Point: 8.7678

>T289634 WP_001312851.1 NZ_LR882061:41685-41834 [Escherichia coli]
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK

Download         Length: 150 bp

Antitoxin


Download         Length: 59 bp

>AT289634 NZ_LR882061:c41638-41580 [Escherichia coli]
AGATACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C8K5

Antitoxin

Download structure file

References