Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4793455..4794057 Replicon chromosome
Accession NZ_LR882057
Organism Escherichia coli isolate 2014-01-7375

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag IHP09_RS23070 Protein ID WP_000897305.1
Coordinates 4793746..4794057 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IHP09_RS23065 Protein ID WP_000356397.1
Coordinates 4793455..4793745 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHP09_RS23040 4789381..4790283 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
IHP09_RS23045 4790280..4790915 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
IHP09_RS23050 4790912..4791841 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
IHP09_RS23055 4792171..4792413 - 243 WP_001086388.1 hypothetical protein -
IHP09_RS23060 4792632..4792850 - 219 WP_001295676.1 ribbon-helix-helix domain-containing protein -
IHP09_RS23065 4793455..4793745 - 291 WP_000356397.1 helix-turn-helix domain-containing protein Antitoxin
IHP09_RS23070 4793746..4794057 - 312 WP_000897305.1 hypothetical protein Toxin
IHP09_RS23075 4794286..4795194 + 909 WP_001162704.1 alpha/beta hydrolase -
IHP09_RS23080 4795258..4796199 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
IHP09_RS23085 4796244..4796681 - 438 WP_000560983.1 D-tyrosyl-tRNA(Tyr) deacylase -
IHP09_RS23090 4796678..4797550 - 873 WP_000920762.1 virulence factor BrkB family protein -
IHP09_RS23095 4797544..4798143 - 600 WP_001315111.1 glucose-1-phosphatase -
IHP09_RS23100 4798242..4799027 - 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T289623 WP_000897305.1 NZ_LR882057:c4794057-4793746 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT289623 WP_000356397.1 NZ_LR882057:c4793745-4793455 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References