Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3959481..3960022 Replicon chromosome
Accession NZ_LR882057
Organism Escherichia coli isolate 2014-01-7375

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag IHP09_RS19185 Protein ID WP_000615976.1
Coordinates 3959744..3960022 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag IHP09_RS19180 Protein ID WP_000729704.1
Coordinates 3959481..3959741 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHP09_RS19155 3955264..3956049 - 786 WP_000207590.1 putative lateral flagellar export/assembly protein LafU -
IHP09_RS19160 3956021..3957733 + 1713 Protein_3753 flagellar biosynthesis protein FlhA -
IHP09_RS19165 3957838..3958116 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
IHP09_RS19170 3958109..3958465 + 357 WP_001030483.1 type II toxin-antitoxin system HicB family antitoxin -
IHP09_RS19175 3958522..3959295 - 774 WP_000543895.1 C40 family peptidase -
IHP09_RS19180 3959481..3959741 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
IHP09_RS19185 3959744..3960022 + 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
IHP09_RS19190 3960178..3960918 + 741 WP_001225679.1 murein L,D-transpeptidase -
IHP09_RS19195 3960889..3961656 - 768 WP_000333380.1 class II glutamine amidotransferase -
IHP09_RS19200 3961862..3962440 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - gmhA/lpcA / rhs/PAAR 3958109..3976659 18550


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T289621 WP_000615976.1 NZ_LR882057:3959744-3960022 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT289621 WP_000729704.1 NZ_LR882057:3959481-3959741 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References