Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 626042..626841 Replicon chromosome
Accession NZ_LR882057
Organism Escherichia coli isolate 2014-01-7375

Toxin (Protein)


Gene name yhaV Uniprot ID U9XVR9
Locus tag IHP09_RS03125 Protein ID WP_000347267.1
Coordinates 626042..626506 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag IHP09_RS03130 Protein ID WP_001307405.1
Coordinates 626506..626841 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHP09_RS03095 621043..621477 - 435 WP_000948824.1 PTS sugar transporter subunit IIA -
IHP09_RS03100 621495..622373 - 879 WP_001298758.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
IHP09_RS03105 622363..623142 - 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
IHP09_RS03110 623153..623626 - 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
IHP09_RS03115 623649..624929 - 1281 WP_000681947.1 tagatose-bisphosphate aldolase subunit KbaZ -
IHP09_RS03120 625178..625987 + 810 WP_000072180.1 aga operon transcriptional regulator AgaR -
IHP09_RS03125 626042..626506 - 465 WP_000347267.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
IHP09_RS03130 626506..626841 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
IHP09_RS03135 626990..628561 - 1572 WP_001273741.1 galactarate dehydratase -
IHP09_RS03140 628936..630270 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
IHP09_RS03145 630286..631056 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17807.17 Da        Isoelectric Point: 9.4947

>T289605 WP_000347267.1 NZ_LR882057:c626506-626042 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT289605 WP_001307405.1 NZ_LR882057:c626841-626506 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XTR4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References