289594

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3544278..3544819 Replicon chromosome
Accession NZ_LR882052
Organism Escherichia coli isolate 2015-01-466

Toxin (Protein)


Gene name yafQ Uniprot ID Q47149
Locus tag QREC_RS16990 Protein ID WP_000615983.1
Coordinates 3544541..3544819 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q47150
Locus tag QREC_RS16985 Protein ID WP_000729703.1
Coordinates 3544278..3544538 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QREC_RS16965 3539953..3540738 - 786 WP_000207552.1 putative lateral flagellar export/assembly protein LafU -
QREC_RS16970 3540710..3542422 + 1713 Protein_3314 flagellar biosynthesis protein FlhA -
QREC_RS16975 3542646..3543143 - 498 WP_000006255.1 REP-associated tyrosine transposase RayT -
QREC_RS16980 3543319..3544068 - 750 WP_000056849.1 C40 family peptidase -
QREC_RS16985 3544278..3544538 + 261 WP_000729703.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
QREC_RS16990 3544541..3544819 + 279 WP_000615983.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
QREC_RS16995 3544975..3545715 + 741 WP_001225679.1 murein L,D-transpeptidase -
QREC_RS17000 3545686..3546453 - 768 WP_000333380.1 class II glutamine amidotransferase -
QREC_RS17005 3546659..3547237 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10846.62 Da        Isoelectric Point: 9.9941

>T289594 WP_000615983.1 NZ_LR882052:3544541-3544819 [Escherichia coli]
MIQRDIEYSGQYSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9405.80 Da        Isoelectric Point: 5.0758

>AT289594 WP_000729703.1 NZ_LR882052:3544278-3544538 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGIDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4Q2U

Antitoxin

Source ID Structure
AlphaFold DB A0A5F1F716

References