Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 3538081..3538775 Replicon chromosome
Accession NZ_LR882052
Organism Escherichia coli isolate 2015-01-466

Toxin (Protein)


Gene name yafO Uniprot ID Q47157
Locus tag QREC_RS16950 Protein ID WP_001263489.1
Coordinates 3538081..3538479 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID S1QAE3
Locus tag QREC_RS16955 Protein ID WP_000554758.1
Coordinates 3538482..3538775 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
- 3533669..3533749 - 81 NuclAT_12 - -
- 3533669..3533749 - 81 NuclAT_12 - -
- 3533669..3533749 - 81 NuclAT_12 - -
- 3533669..3533749 - 81 NuclAT_12 - -
QREC_RS16925 3534345..3534803 - 459 WP_001291990.1 xanthine phosphoribosyltransferase -
QREC_RS16930 3535064..3536521 + 1458 WP_001292994.1 cytosol nonspecific dipeptidase -
QREC_RS16935 3536578..3537099 - 522 Protein_3307 peptide chain release factor H -
QREC_RS16940 3537095..3537301 - 207 Protein_3308 RtcB family protein -
QREC_RS16945 3537619..3538071 - 453 WP_001059892.1 GNAT family N-acetyltransferase -
QREC_RS16950 3538081..3538479 - 399 WP_001263489.1 type II toxin-antitoxin system mRNA interferase toxin YafO Toxin
QREC_RS16955 3538482..3538775 - 294 WP_000554758.1 type I toxin-antitoxin system antitoxin YafN Antitoxin
QREC_RS16960 3538827..3539882 - 1056 WP_001226164.1 DNA polymerase IV -
QREC_RS16965 3539953..3540738 - 786 WP_000207552.1 putative lateral flagellar export/assembly protein LafU -
QREC_RS16970 3540710..3542422 + 1713 Protein_3314 flagellar biosynthesis protein FlhA -
QREC_RS16975 3542646..3543143 - 498 WP_000006255.1 REP-associated tyrosine transposase RayT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(27-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15487.84 Da        Isoelectric Point: 7.4215

>T289593 WP_001263489.1 NZ_LR882052:c3538479-3538081 [Escherichia coli]
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANENNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKLARDNNQMHKIGKMAEAFRMRF

Download         Length: 399 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11233.76 Da        Isoelectric Point: 5.2170

>AT289593 WP_000554758.1 NZ_LR882052:c3538775-3538482 [Escherichia coli]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EQYLNDMTDDDFNDFKE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A090J8B1

Antitoxin

Source ID Structure
AlphaFold DB S1QAE3

References