289584

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1764631..1765133 Replicon chromosome
Accession NZ_LR882052
Organism Escherichia coli isolate 2015-01-466

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag QREC_RS08305 Protein ID WP_000767829.1
Coordinates 1764879..1765133 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag QREC_RS08300 Protein ID WP_001259255.1
Coordinates 1764631..1764882 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QREC_RS08275 1759808..1760875 - 1068 WP_000080055.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
QREC_RS08280 1760875..1761945 - 1071 WP_000108933.1 histidinol-phosphate transaminase -
QREC_RS08285 1761942..1763246 - 1305 WP_001352244.1 histidinol dehydrogenase -
QREC_RS08290 1763252..1764151 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
QREC_RS08295 1764297..1764347 - 51 WP_001364200.1 his operon leader peptide -
QREC_RS08300 1764631..1764882 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QREC_RS08305 1764879..1765133 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QREC_RS08310 1765216..1766040 + 825 WP_000754737.1 SDR family oxidoreductase -
QREC_RS08315 1766086..1767015 + 930 WP_000803366.1 LysR family transcriptional regulator -
QREC_RS08320 1767230..1767292 + 63 WP_010723108.1 membrane protein YoeI -
QREC_RS08325 1767282..1768640 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
QREC_RS08330 1768819..1769877 + 1059 WP_000492346.1 transport protein YeeE -
QREC_RS08335 1769891..1770118 + 228 WP_000985272.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T289584 WP_000767829.1 NZ_LR882052:1764879-1765133 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT289584 WP_001259255.1 NZ_LR882052:1764631-1764882 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References