Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1764631..1765133 Replicon chromosome
Accession NZ_LR882052
Organism Escherichia coli isolate 2015-01-466

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag QREC_RS08305 Protein ID WP_000767829.1
Coordinates 1764879..1765133 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag QREC_RS08300 Protein ID WP_001259255.1
Coordinates 1764631..1764882 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QREC_RS08275 1759808..1760875 - 1068 WP_000080055.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
QREC_RS08280 1760875..1761945 - 1071 WP_000108933.1 histidinol-phosphate transaminase -
QREC_RS08285 1761942..1763246 - 1305 WP_001352244.1 histidinol dehydrogenase -
QREC_RS08290 1763252..1764151 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
QREC_RS08295 1764297..1764347 - 51 WP_001364200.1 his operon leader peptide -
QREC_RS08300 1764631..1764882 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QREC_RS08305 1764879..1765133 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QREC_RS08310 1765216..1766040 + 825 WP_000754737.1 SDR family oxidoreductase -
QREC_RS08315 1766086..1767015 + 930 WP_000803366.1 LysR family transcriptional regulator -
QREC_RS08320 1767230..1767292 + 63 WP_010723108.1 membrane protein YoeI -
QREC_RS08325 1767282..1768640 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
QREC_RS08330 1768819..1769877 + 1059 WP_000492346.1 transport protein YeeE -
QREC_RS08335 1769891..1770118 + 228 WP_000985272.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T289584 WP_000767829.1 NZ_LR882052:1764879-1765133 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT289584 WP_001259255.1 NZ_LR882052:1764631-1764882 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References