Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 5263255..5263920 Replicon chromosome
Accession NZ_LR881953
Organism Streptomyces sp. KY75 isolate Streptomyces sp. KY75

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag JOA52_RS23965 Protein ID WP_202592594.1
Coordinates 5263255..5263575 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JOA52_RS23970 Protein ID WP_076965814.1
Coordinates 5263582..5263920 (+) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JOA52_RS23945 5259036..5259230 + 195 WP_015611142.1 hypothetical protein -
JOA52_RS23950 5259371..5260342 + 972 WP_202591646.1 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha- D-glucopyranoside deacetylase -
JOA52_RS23955 5260339..5260872 + 534 WP_202591647.1 hypothetical protein -
JOA52_RS23960 5261048..5263258 + 2211 WP_202591648.1 hypothetical protein -
JOA52_RS23965 5263255..5263575 + 321 WP_202592594.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JOA52_RS23970 5263582..5263920 + 339 WP_076965814.1 XRE family transcriptional regulator Antitoxin
JOA52_RS23975 5264288..5266108 - 1821 WP_202591649.1 coagulation factor 5/8 type domain-containing protein -
JOA52_RS23980 5266429..5266974 + 546 WP_076965816.1 DUF4265 domain-containing protein -
JOA52_RS23985 5267057..5267623 - 567 WP_202592595.1 sugar O-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(26-99)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-95)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 11153.72 Da        Isoelectric Point: 10.5206

>T289559 WP_202592594.1 NZ_LR881953:5263255-5263575 [Streptomyces sp. KY75]
MSLPARTPSTAPARTPRAGAAAILIEGPALGRPLVDRITGSALANLKELRPGSSGSSEVRILFVFDPARNAVILVGGDKS
GSWSGWYRTAIKAAEDAYEAYRDAKK

Download         Length: 321 bp

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 11998.60 Da        Isoelectric Point: 5.7529

>AT289559 WP_076965814.1 NZ_LR881953:5263582-5263920 [Streptomyces sp. KY75]
VSAERKAADAVDWDDLKGEFGLSEGETHEVDRRAALLLSQVRAHRLAEVRKRQQMTQAAVAKVLGVTQGRVSAIEKGAIN
RSEVETLAAYVAALGGQLKLVADFGDETLVLG

Download         Length: 339 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References