Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2574125..2574790 Replicon chromosome
Accession NZ_LR881952
Organism Streptomyces sp. KY70 isolate Streptomyces sp. KY70

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag STRPST75_RS11015 Protein ID WP_202592594.1
Coordinates 2574470..2574790 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag STRPST75_RS11010 Protein ID WP_076965814.1
Coordinates 2574125..2574463 (-) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
STRPST75_RS10995 2570422..2570988 + 567 WP_202592595.1 sugar O-acetyltransferase -
STRPST75_RS11000 2571071..2571616 - 546 WP_076965816.1 DUF4265 domain-containing protein -
STRPST75_RS11005 2571937..2573757 + 1821 WP_202591649.1 coagulation factor 5/8 type domain-containing protein -
STRPST75_RS11010 2574125..2574463 - 339 WP_076965814.1 XRE family transcriptional regulator Antitoxin
STRPST75_RS11015 2574470..2574790 - 321 WP_202592594.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
STRPST75_RS11020 2574787..2575719 - 933 WP_164238214.1 hypothetical protein -
STRPST75_RS11025 2577168..2577701 - 534 WP_202591647.1 hypothetical protein -
STRPST75_RS11030 2577698..2578669 - 972 WP_202591646.1 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha- D-glucopyranoside deacetylase -
STRPST75_RS11035 2578810..2579004 - 195 WP_015611142.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(26-99)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-95)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 11153.72 Da        Isoelectric Point: 10.5206

>T289556 WP_202592594.1 NZ_LR881952:c2574790-2574470 [Streptomyces sp. KY70]
MSLPARTPSTAPARTPRAGAAAILIEGPALGRPLVDRITGSALANLKELRPGSSGSSEVRILFVFDPARNAVILVGGDKS
GSWSGWYRTAIKAAEDAYEAYRDAKK

Download         Length: 321 bp

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 11998.60 Da        Isoelectric Point: 5.7529

>AT289556 WP_076965814.1 NZ_LR881952:c2574463-2574125 [Streptomyces sp. KY70]
VSAERKAADAVDWDDLKGEFGLSEGETHEVDRRAALLLSQVRAHRLAEVRKRQQMTQAAVAKVLGVTQGRVSAIEKGAIN
RSEVETLAAYVAALGGQLKLVADFGDETLVLG

Download         Length: 339 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References