Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3694827..3695368 Replicon chromosome
Accession NZ_LR881940
Organism Escherichia coli isolate 2015-01-2097

Toxin (Protein)


Gene name yafQ Uniprot ID S1FHQ9
Locus tag IHP11_RS17915 Protein ID WP_000615979.1
Coordinates 3695090..3695368 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag IHP11_RS17910 Protein ID WP_000729704.1
Coordinates 3694827..3695087 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHP11_RS17890 3690510..3691295 - 786 WP_072132640.1 putative lateral flagellar export/assembly protein LafU -
IHP11_RS17895 3691267..3692979 + 1713 Protein_3502 flagellar biosynthesis protein FlhA -
IHP11_RS17900 3693195..3693692 - 498 WP_000006261.1 REP-associated tyrosine transposase RayT -
IHP11_RS17905 3693868..3694641 - 774 WP_001353765.1 C40 family peptidase -
IHP11_RS17910 3694827..3695087 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
IHP11_RS17915 3695090..3695368 + 279 WP_000615979.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
IHP11_RS17920 3695524..3696264 + 741 WP_001225679.1 murein L,D-transpeptidase -
IHP11_RS17925 3696235..3697002 - 768 WP_000333379.1 class II glutamine amidotransferase -
IHP11_RS17930 3697208..3697786 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10830.62 Da        Isoelectric Point: 10.0702

>T289552 WP_000615979.1 NZ_LR881940:3695090-3695368 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT289552 WP_000729704.1 NZ_LR881940:3694827-3695087 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1FHQ9

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References