Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 657412..658139 Replicon chromosome
Accession NZ_LR881940
Organism Escherichia coli isolate 2015-01-2097

Toxin (Protein)


Gene name higB Uniprot ID U9ZMR4
Locus tag IHP11_RS03195 Protein ID WP_000550189.1
Coordinates 657412..657726 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IHP11_RS03200 Protein ID WP_191521707.1
Coordinates 657723..658139 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHP11_RS03175 653570..654556 - 987 WP_000617698.1 Gfo/Idh/MocA family oxidoreductase -
IHP11_RS03180 654635..655327 - 693 WP_000942548.1 vancomycin high temperature exclusion protein -
IHP11_RS03185 655404..655907 - 504 WP_001300832.1 M48 family metallopeptidase -
IHP11_RS03190 655992..657128 + 1137 WP_000018695.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
IHP11_RS03195 657412..657726 + 315 WP_000550189.1 type II toxin-antitoxin system toxin HigB Toxin
IHP11_RS03200 657723..658139 + 417 WP_191521707.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
IHP11_RS03205 658184..660202 - 2019 WP_191521708.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
IHP11_RS03210 660628..662979 - 2352 WP_000695488.1 alpha-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Antitoxin HigA

(1-138)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12103.10 Da        Isoelectric Point: 10.0409

>T289537 WP_000550189.1 NZ_LR881940:657412-657726 [Escherichia coli]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK

Download         Length: 315 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15023.47 Da        Isoelectric Point: 4.4547

>AT289537 WP_191521707.1 NZ_LR881940:657723-658139 [Escherichia coli]
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMAQVMPGG
IAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6KMQ
PDB 5IFG
PDB 5YCL
PDB 6KML

Antitoxin

Source ID Structure

References