Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 614067..614866 Replicon chromosome
Accession NZ_LR881940
Organism Escherichia coli isolate 2015-01-2097

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag IHP11_RS02975 Protein ID WP_000347251.1
Coordinates 614067..614531 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag IHP11_RS02980 Protein ID WP_001307405.1
Coordinates 614531..614866 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHP11_RS02945 609068..609502 - 435 WP_000948824.1 PTS sugar transporter subunit IIA -
IHP11_RS02950 609520..610398 - 879 WP_001300474.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
IHP11_RS02955 610388..611167 - 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
IHP11_RS02960 611178..611651 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
IHP11_RS02965 611674..612954 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
IHP11_RS02970 613203..614012 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
IHP11_RS02975 614067..614531 - 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
IHP11_RS02980 614531..614866 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
IHP11_RS02985 615015..616586 - 1572 WP_191521705.1 galactarate dehydratase -
IHP11_RS02990 616961..618295 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
IHP11_RS02995 618311..619081 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T289536 WP_000347251.1 NZ_LR881940:c614531-614067 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT289536 WP_001307405.1 NZ_LR881940:c614866-614531 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References