Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3151342..3152035 Replicon chromosome
Accession NZ_LR881938
Organism Escherichia coli str. K-12 substr. MG1655 strain K-12

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag IEU92_RS15280 Protein ID WP_000415584.1
Coordinates 3151739..3152035 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag IEU92_RS15275 Protein ID WP_000650107.1
Coordinates 3151342..3151737 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IEU92_RS15265 3147206..3149464 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
IEU92_RS15270 3149602..3151209 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
IEU92_RS15275 3151342..3151737 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
IEU92_RS15280 3151739..3152035 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
IEU92_RS15285 3152240..3152722 - 483 WP_000183505.1 transcriptional regulator -
IEU92_RS15290 3152775..3153167 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
IEU92_RS15295 3153319..3153978 + 660 WP_001221495.1 two-component system response regulator QseB -
IEU92_RS15300 3153975..3155324 + 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
IEU92_RS15305 3155370..3155702 - 333 WP_000917684.1 DUF2645 family protein -
IEU92_RS15310 3156021..3156602 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
IEU92_RS15315 3156633..3156947 + 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T289525 WP_000415584.1 NZ_LR881938:c3152035-3151739 [Escherichia coli str. K-12 substr. MG1655]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT289525 WP_000650107.1 NZ_LR881938:c3151737-3151342 [Escherichia coli str. K-12 substr. MG1655]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References