Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2072704..2073206 Replicon chromosome
Accession NZ_LR881938
Organism Escherichia coli str. K-12 substr. MG1655 strain K-12

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag IEU92_RS10250 Protein ID WP_000767829.1
Coordinates 2072704..2072958 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag IEU92_RS10255 Protein ID WP_001259255.1
Coordinates 2072955..2073206 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IEU92_RS10220 2067719..2067946 - 228 WP_000234896.1 sulfurtransferase TusA -
IEU92_RS10225 2067960..2069018 - 1059 WP_000492339.1 transport protein YeeE -
IEU92_RS10230 2069197..2070555 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
IEU92_RS10235 2070545..2070607 - 63 WP_010723108.1 membrane protein YoeI -
IEU92_RS10240 2070822..2071751 - 930 WP_000803351.1 LysR family transcriptional regulator -
IEU92_RS10245 2071797..2072621 - 825 WP_000754737.1 SDR family oxidoreductase -
IEU92_RS10250 2072704..2072958 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
IEU92_RS10255 2072955..2073206 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
IEU92_RS10260 2073489..2073539 + 51 WP_001364200.1 his operon leader peptide -
IEU92_RS10265 2073685..2074584 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
IEU92_RS10270 2074590..2075894 + 1305 WP_000009594.1 histidinol dehydrogenase -
IEU92_RS10275 2075891..2076961 + 1071 WP_000108941.1 histidinol-phosphate transaminase -
IEU92_RS10280 2076961..2078028 + 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T289520 WP_000767829.1 NZ_LR881938:c2072958-2072704 [Escherichia coli str. K-12 substr. MG1655]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT289520 WP_001259255.1 NZ_LR881938:c2073206-2072955 [Escherichia coli str. K-12 substr. MG1655]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References