289520

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2072704..2073206 Replicon chromosome
Accession NZ_LR881938
Organism Escherichia coli str. K-12 substr. MG1655 strain K-12

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag IEU92_RS10250 Protein ID WP_000767829.1
Coordinates 2072704..2072958 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag IEU92_RS10255 Protein ID WP_001259255.1
Coordinates 2072955..2073206 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IEU92_RS10220 2067719..2067946 - 228 WP_000234896.1 sulfurtransferase TusA -
IEU92_RS10225 2067960..2069018 - 1059 WP_000492339.1 transport protein YeeE -
IEU92_RS10230 2069197..2070555 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
IEU92_RS10235 2070545..2070607 - 63 WP_010723108.1 membrane protein YoeI -
IEU92_RS10240 2070822..2071751 - 930 WP_000803351.1 LysR family transcriptional regulator -
IEU92_RS10245 2071797..2072621 - 825 WP_000754737.1 SDR family oxidoreductase -
IEU92_RS10250 2072704..2072958 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
IEU92_RS10255 2072955..2073206 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
IEU92_RS10260 2073489..2073539 + 51 WP_001364200.1 his operon leader peptide -
IEU92_RS10265 2073685..2074584 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
IEU92_RS10270 2074590..2075894 + 1305 WP_000009594.1 histidinol dehydrogenase -
IEU92_RS10275 2075891..2076961 + 1071 WP_000108941.1 histidinol-phosphate transaminase -
IEU92_RS10280 2076961..2078028 + 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T289520 WP_000767829.1 NZ_LR881938:c2072958-2072704 [Escherichia coli str. K-12 substr. MG1655]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT289520 WP_001259255.1 NZ_LR881938:c2073206-2072955 [Escherichia coli str. K-12 substr. MG1655]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References