Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1269550..1270223 Replicon chromosome
Accession NZ_LR881936
Organism Enterobacter cancerogenus strain UPC1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag ENTER_RS05995 Protein ID WP_101738092.1
Coordinates 1269550..1269936 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID D2ZGH8
Locus tag ENTER_RS06000 Protein ID WP_006177062.1
Coordinates 1269939..1270223 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ENTER_RS05980 1265176..1266648 - 1473 WP_202561810.1 betaine-aldehyde dehydrogenase -
ENTER_RS05985 1266662..1267249 - 588 WP_202561811.1 transcriptional regulator BetI -
ENTER_RS05990 1267378..1269411 + 2034 WP_202561812.1 choline transporter -
ENTER_RS05995 1269550..1269936 + 387 WP_101738092.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ENTER_RS06000 1269939..1270223 + 285 WP_006177062.1 helix-turn-helix domain-containing protein Antitoxin
ENTER_RS06005 1270459..1271370 + 912 WP_202561813.1 metal ABC transporter substrate-binding protein -
ENTER_RS06010 1271373..1272176 + 804 WP_137271742.1 iron/manganese ABC transporter ATP-binding protein SitB -
ENTER_RS06015 1272173..1273030 + 858 WP_202561814.1 metal ABC transporter permease -
ENTER_RS06020 1273027..1273866 + 840 WP_006177066.1 metal ABC transporter permease -
ENTER_RS06025 1273829..1274497 - 669 WP_202561815.1 enterobactin synthase subunit EntD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(38-116)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-87)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14346.53 Da        Isoelectric Point: 9.7081

>T289492 WP_101738092.1 NZ_LR881936:1269550-1269936 [Enterobacter cancerogenus]
MSHALEFIETSLFTRQIKSIASDDELKDLQKELIAWPDKGDVIQHTGGLRKIRMAAGSKGKRGGARVIYFLATEEVIYLI
MAYPKNTKDTLTETEKAQLKKLTSVLRNTASNALDERCTMYPNQVRGG

Download         Length: 387 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10407.85 Da        Isoelectric Point: 10.0004

>AT289492 WP_006177062.1 NZ_LR881936:1269939-1270223 [Enterobacter cancerogenus]
MSIFEELKSSLEEAVEIHSGKKTPSRVTRYEVADVRAIREQLNVTQSEMAKALGTSVDTIKSWESKRRNPTGLAAKVLKA
IRDNPAFYSALAGQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB D2ZGH8

References