Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 364041..364707 Replicon chromosome
Accession NZ_LR881934
Organism Citrobacter freundii strain PSV

Toxin (Protein)


Gene name higB Uniprot ID A0A8B5Q945
Locus tag CITRO_RS01710 Protein ID WP_003847996.1
Coordinates 364390..364707 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CITRO_RS01705 Protein ID WP_049001470.1
Coordinates 364041..364337 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CITRO_RS01690 361217..361690 - 474 WP_003023524.1 transcription elongation factor GreB -
CITRO_RS01695 361916..362635 + 720 WP_001157751.1 two-component system response regulator OmpR -
CITRO_RS01700 362632..363984 + 1353 WP_003837891.1 two-component system sensor histidine kinase EnvZ -
CITRO_RS01705 364041..364337 - 297 WP_049001470.1 helix-turn-helix domain-containing protein Antitoxin
CITRO_RS01710 364390..364707 - 318 WP_003847996.1 hypothetical protein Toxin
CITRO_RS01715 364830..366452 - 1623 WP_003023529.1 phosphoenolpyruvate carboxykinase (ATP) -
CITRO_RS01720 366831..368549 + 1719 WP_202580951.1 DUF4153 domain-containing protein -
CITRO_RS01725 368659..369537 - 879 WP_003023531.1 Hsp33 family molecular chaperone HslO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(39-75)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12225.15 Da        Isoelectric Point: 10.0909

>T289474 WP_003847996.1 NZ_LR881934:c364707-364390 [Citrobacter freundii]
MFTFIELQGFSKRRPLLLPDDEFRAFQEALIENPEAGDTIAGTGGFRKIRWSRSGMGKRSGIRVIYYNVTRKGRIYLALL
YPKNEQDDLTEEQKRVLMHLSNMLI

Download         Length: 318 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11147.89 Da        Isoelectric Point: 7.2050

>AT289474 WP_049001470.1 NZ_LR881934:c364337-364041 [Citrobacter freundii]
MKDELFADLLASAEEMVRIEKGEETPKSEHVHTFSEIDVKAIREATGLRQQDFAIAVGVSYDLVKSWETKRRQPTGAPRK
LLLLIQKNPFIINQLKAI

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B5Q945

Antitoxin

Source ID Structure

References