Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3373391..3374009 Replicon chromosome
Accession NZ_LR878365
Organism Shigella flexneri 3a isolate 83

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag JMV05_RS17225 Protein ID WP_001291435.1
Coordinates 3373791..3374009 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q0T7C3
Locus tag JMV05_RS17220 Protein ID WP_000344797.1
Coordinates 3373391..3373765 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV05_RS17210 (3368480) 3368480..3369673 + 1194 WP_024260158.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JMV05_RS17215 (3369696) 3369696..3372845 + 3150 WP_001132472.1 efflux RND transporter permease AcrB -
JMV05_RS17220 (3373391) 3373391..3373765 + 375 WP_000344797.1 Hha toxicity modulator TomB Antitoxin
JMV05_RS17225 (3373791) 3373791..3374009 + 219 WP_001291435.1 HHA domain-containing protein Toxin
JMV05_RS17230 (3374181) 3374181..3374732 + 552 WP_000102569.1 maltose O-acetyltransferase -
JMV05_RS17235 (3374848) 3374848..3375318 + 471 WP_000136192.1 YlaC family protein -
JMV05_RS17240 (3375482) 3375482..3377032 + 1551 WP_025758198.1 cyclic-guanylate-specific phosphodiesterase PdeB -
JMV05_RS17245 (3377074) 3377074..3377427 - 354 WP_000878140.1 DUF1428 domain-containing protein -
JMV05_RS17255 (3377806) 3377806..3378117 + 312 WP_000409911.1 MGMT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 3378147..3379475 1328


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T289454 WP_001291435.1 NZ_LR878365:3373791-3374009 [Shigella flexneri 3a]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14513.38 Da        Isoelectric Point: 4.9091

>AT289454 WP_000344797.1 NZ_LR878365:3373391-3373765 [Shigella flexneri 3a]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQALQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A4P7TPD8

References