Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3113946..3114474 Replicon chromosome
Accession NZ_LR878365
Organism Shigella flexneri 3a isolate 83

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JMV05_RS15900 Protein ID WP_236743520.1
Coordinates 3113946..3114176 (+) Length 77 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID Q32DW6
Locus tag JMV05_RS15905 Protein ID WP_000147081.1
Coordinates 3114166..3114474 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV05_RS15870 (3109462) 3109462..3109677 + 216 Protein_3103 transposase domain-containing protein -
JMV05_RS15875 (3109708) 3109708..3110955 - 1248 Protein_3104 replicative DNA helicase -
JMV05_RS15880 (3110952) 3110952..3111830 - 879 WP_000988187.1 ATP-binding protein -
JMV05_RS15885 (3111841) 3111841..3112748 - 908 Protein_3106 DNA-binding protein -
JMV05_RS15890 (3112735) 3112735..3112968 - 234 WP_000618004.1 hypothetical protein -
JMV05_RS15895 (3112965) 3112965..3113933 - 969 WP_000961310.1 Rha family phage regulatory protein -
JMV05_RS15900 (3113946) 3113946..3114176 + 231 WP_236743520.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMV05_RS15905 (3114166) 3114166..3114474 + 309 WP_000147081.1 helix-turn-helix transcriptional regulator Antitoxin
JMV05_RS15910 (3114516) 3114516..3114692 - 177 WP_001254220.1 NinE family protein -
JMV05_RS15915 (3114689) 3114689..3115099 - 411 WP_000814621.1 recombination protein NinB -
JMV05_RS15920 (3115096) 3115096..3115374 - 279 WP_025757756.1 hypothetical protein -
JMV05_RS15925 (3115449) 3115449..3117797 - 2349 Protein_3114 toprim domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - ipaH4.5 / ipaH9.8 3061665..3139660 77995


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(5-70)

Antitoxin

Cro/C1-type helix-turn-helix domain

(44-97)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8695.15 Da        Isoelectric Point: 10.5308

>T289453 WP_236743520.1 NZ_LR878365:3113946-3114176 [Shigella flexneri 3a]
MKVYGSNLGEPHTSAFGDGLFELRIKGNDGIARVFYCTLTGKRIIMLHSFVKKTQKTPPAERKKAETRMKEVKHDW

Download         Length: 231 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11185.94 Da        Isoelectric Point: 8.5840

>AT289453 WP_000147081.1 NZ_LR878365:3114166-3114474 [Shigella flexneri 3a]
MTGKRTLPTMTHDEMAAKWMEDPAFKAEYDAIADEFALLDEMLAARKEAGLTQAEVAERMGTKATAITRMESNLASGISG
PSFATLKKFARATGKKLQIRFV

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A4P7TJC1

References