Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 645009..645736 Replicon chromosome
Accession NZ_LR878365
Organism Shigella flexneri 3a isolate 83

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JMV05_RS03195 Protein ID WP_119182032.1
Coordinates 645009..645323 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JMV05_RS03200 Protein ID WP_000560266.1
Coordinates 645320..645736 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV05_RS03175 (641154) 641154..642152 - 999 WP_005050984.1 Gfo/Idh/MocA family oxidoreductase -
JMV05_RS03180 (642231) 642231..642923 - 693 WP_000942537.1 vancomycin high temperature exclusion protein -
JMV05_RS03185 (643000) 643000..643503 - 504 WP_005071012.1 M48 family metallopeptidase -
JMV05_RS03190 (643588) 643588..644724 + 1137 WP_000018657.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
JMV05_RS03195 (645009) 645009..645323 + 315 WP_119182032.1 type II toxin-antitoxin system toxin HigB Toxin
JMV05_RS03200 (645320) 645320..645736 + 417 WP_000560266.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
JMV05_RS03205 (645781) 645781..647799 - 2019 WP_040235166.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
JMV05_RS03210 (648025) 648025..650376 - 2352 WP_000695506.1 alpha-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-135)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12077.07 Da        Isoelectric Point: 10.1027

>T289442 WP_119182032.1 NZ_LR878365:645009-645323 [Shigella flexneri 3a]
MHLITQKALKDAAEKHPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK

Download         Length: 315 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 14995.42 Da        Isoelectric Point: 4.4547

>AT289442 WP_000560266.1 NZ_LR878365:645320-645736 [Shigella flexneri 3a]
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGG
IAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References