Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 914479..915068 Replicon chromosome
Accession NZ_LR828257
Organism Xanthomonas hortorum pv. vitians strain CFBP 498

Toxin (Protein)


Gene name graT Uniprot ID A0A6V7BZM8
Locus tag CFBP8129_RS03830 Protein ID WP_074058684.1
Coordinates 914479..914760 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0Q5FN17
Locus tag CFBP8129_RS03835 Protein ID WP_055829449.1
Coordinates 914778..915068 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFBP8129_RS03820 910827..913070 + 2244 WP_183153053.1 exodeoxyribonuclease V subunit alpha -
CFBP8129_RS03825 913209..914264 + 1056 WP_074058685.1 virulence RhuM family protein -
CFBP8129_RS03830 914479..914760 + 282 WP_074058684.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CFBP8129_RS03835 914778..915068 + 291 WP_055829449.1 HigA family addiction module antidote protein Antitoxin
CFBP8129_RS03840 915191..915934 - 744 WP_074058683.1 SDR family oxidoreductase -
CFBP8129_RS03845 916153..916971 + 819 WP_197970278.1 AraC family transcriptional regulator -
CFBP8129_RS03850 917589..917921 - 333 WP_074058681.1 hypothetical protein -
CFBP8129_RS03855 918314..918592 - 279 WP_180313725.1 hypothetical protein -
CFBP8129_RS03860 918715..919644 - 930 WP_180313726.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-68)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11031.71 Da        Isoelectric Point: 10.2121

>T289428 WP_074058684.1 NZ_LR828257:914479-914760 [Xanthomonas hortorum pv. vitians]
MIRSFVDKEAEKIWLGERSRRLPADIQSVARRKLRMLNAAAHLDDLRIPPANRLEALKGQRRGQYSIRINDQWRICFRWM
EGDVAEVDIVDYH

Download         Length: 282 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10497.17 Da        Isoelectric Point: 6.4675

>AT289428 WP_055829449.1 NZ_LR828257:914778-915068 [Xanthomonas hortorum pv. vitians]
MTVLPNIHPGEILLEEFLEPMGISQNALARATAVPPRRINEIVLGKRGITADTAVRLAAALGTTERFWLGLQADYELEEA
HRALGDLPSRIKRLAA

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6V7BZM8

Antitoxin

Source ID Structure
AlphaFold DB A0A0Q5FN17

References