Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5084148..5084737 Replicon chromosome
Accession NZ_LR828253
Organism Xanthomonas hortorum pv. gardneri strain CFBP 8129

Toxin (Protein)


Gene name graT Uniprot ID F0C464
Locus tag CFBP498_RS21750 Protein ID WP_006449988.1
Coordinates 5084456..5084737 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CFBP498_RS21745 Protein ID WP_006449989.1
Coordinates 5084148..5084438 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFBP498_RS21730 (CFBP8129_44310) 5079849..5080829 + 981 WP_074065938.1 IS5 family transposase -
CFBP498_RS21735 (CFBP8129_44320) 5081045..5082640 - 1596 WP_006449992.1 anti-phage dCTP deaminase -
CFBP498_RS21740 (CFBP8129_44330) 5083282..5083614 + 333 WP_006449991.1 hypothetical protein -
CFBP498_RS23870 5083767..5083957 + 191 Protein_4273 hypothetical protein -
CFBP498_RS21745 (CFBP8129_44350) 5084148..5084438 - 291 WP_006449989.1 HigA family addiction module antitoxin Antitoxin
CFBP498_RS21750 (CFBP8129_44360) 5084456..5084737 - 282 WP_006449988.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CFBP498_RS21755 (CFBP8129_44370) 5084951..5086006 - 1056 WP_006449987.1 virulence RhuM family protein -
CFBP498_RS21760 (CFBP8129_44380) 5086217..5088367 - 2151 WP_228996014.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 5079849..5080829 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11044.69 Da        Isoelectric Point: 9.7972

>T289427 WP_006449988.1 NZ_LR828253:c5084737-5084456 [Xanthomonas hortorum pv. gardneri]
VIRSFIDKEAEKIWLGERSRRLPSDIQSVARRKLRMLNAAAHLDDLRIPPANRLEALKGERRGQYSIRINDQWRICFRWM
EGDVAEVEIVDYH

Download         Length: 282 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10540.20 Da        Isoelectric Point: 6.4664

>AT289427 WP_006449989.1 NZ_LR828253:c5084438-5084148 [Xanthomonas hortorum pv. gardneri]
MTVLPNIHPGEILLEEFLEPMGISQNALARATDVPPRRINEIVLGKRGITADTAVRLAAALGTTERFWLGLQADYELEQA
HRALGDLPSRIKRLAA

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6V7F8V8

Antitoxin

Source ID Structure

References