Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2508077..2508594 Replicon chromosome
Accession NZ_LR822061
Organism Staphylococcus aureus isolate HU-14

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3A3ATA4
Locus tag BKMNNEJI_RS12465 Protein ID WP_000113265.1
Coordinates 2508328..2508594 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag BKMNNEJI_RS12460 Protein ID WP_000584499.1
Coordinates 2508077..2508328 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BKMNNEJI_RS12430 2503774..2504493 + 720 WP_000479576.1 amino acid ABC transporter permease -
BKMNNEJI_RS12435 2504490..2505221 + 732 WP_000615456.1 amino acid ABC transporter ATP-binding protein -
BKMNNEJI_RS12440 2505318..2506568 - 1251 WP_001012225.1 FemA/FemB family glycyltransferase FmhA -
BKMNNEJI_RS12445 2506824..2507186 + 363 WP_000819843.1 DUF4467 domain-containing protein -
BKMNNEJI_RS12450 2507205..2507804 + 600 WP_000162810.1 DsbA family protein -
BKMNNEJI_RS12455 2507811..2507912 + 102 Protein_2422 hypothetical protein -
BKMNNEJI_RS12460 2508077..2508328 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BKMNNEJI_RS12465 2508328..2508594 + 267 WP_000113265.1 Txe/YoeB family addiction module toxin Toxin
BKMNNEJI_RS12470 2508629..2508700 + 72 Protein_2425 hypothetical protein -
BKMNNEJI_RS12475 2508889..2510436 + 1548 WP_000727772.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
BKMNNEJI_RS12480 2510622..2511089 + 468 WP_000153347.1 SRPBCC domain-containing protein -
BKMNNEJI_RS12485 2511173..2511355 + 183 WP_000230292.1 hypothetical protein -
BKMNNEJI_RS12490 2511572..2512396 + 825 WP_000572038.1 formate/nitrite transporter family protein -
BKMNNEJI_RS12495 2512630..2513166 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.0573

>T289417 WP_000113265.1 NZ_LR822061:2508328-2508594 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT289417 WP_000584499.1 NZ_LR822061:2508077-2508328 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BWF

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References