Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2482914..2483098 Replicon chromosome
Accession NZ_LR822061
Organism Staphylococcus aureus isolate HU-14

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag BKMNNEJI_RS12330 Protein ID WP_000482652.1
Coordinates 2482914..2483021 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2483038..2483098 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BKMNNEJI_RS12305 2478276..2478749 + 474 WP_000456486.1 GyrI-like domain-containing protein -
BKMNNEJI_RS12310 2478872..2480083 - 1212 WP_001192075.1 multidrug effflux MFS transporter -
BKMNNEJI_RS12315 2480265..2480924 - 660 WP_000831302.1 hypothetical protein -
BKMNNEJI_RS12320 2480984..2482126 - 1143 WP_001176863.1 glycerate kinase -
BKMNNEJI_RS12325 2482394..2482780 + 387 WP_000779360.1 flippase GtxA -
BKMNNEJI_RS12330 2482914..2483021 + 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
- 2483038..2483098 - 61 - - Antitoxin
BKMNNEJI_RS12335 2483724..2485487 + 1764 WP_001064825.1 ABC transporter ATP-binding protein/permease -
BKMNNEJI_RS12340 2485512..2487245 + 1734 WP_000486483.1 ABC transporter ATP-binding protein/permease -
BKMNNEJI_RS12345 2487476..2487643 + 168 Protein_2400 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T289416 WP_000482652.1 NZ_LR822061:2482914-2483021 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

Antitoxin


Download         Length: 61 bp

>AT289416 NZ_LR822061:c2483098-2483038 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References