Detailed information of TA system TA289410

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 507701..508280
• Replicon: chromosome
• Accession: NZ_LR822061
• Organism: Staphylococcus aureus isolate HU-14

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: BKMNNEJI_RS02745
• Protein ID: WP_001025401.1
• Coordinates: 507701..507946 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	507915..508280 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BKMNNEJI_RS02695	503951..504565	+	615	WP_000191459.1	hypothetical protein	-
BKMNNEJI_RS02700	504562..504708	-	147	WP_001013104.1	hypothetical protein	-
BKMNNEJI_RS02705	504744..504926	-	183	WP_000705240.1	hypothetical protein	-
BKMNNEJI_RS02710	504997..505728	-	732	WP_000511090.1	XRE family transcriptional regulator	-
BKMNNEJI_RS02715	505880..506092	+	213	WP_000213811.1	helix-turn-helix transcriptional regulator	-
BKMNNEJI_RS02720	506140..506583	+	444	WP_000435357.1	hypothetical protein	-
BKMNNEJI_RS02725	506598..506747	+	150	WP_000771849.1	hypothetical protein	-
BKMNNEJI_RS02730	506788..507000	-	213	WP_000362644.1	hypothetical protein	-
BKMNNEJI_RS02735	507070..507267	+	198	WP_001148860.1	hypothetical protein	-
BKMNNEJI_RS02740	507254..507634	-	381	WP_000773059.1	DUF2513 domain-containing protein	-
BKMNNEJI_RS02745	507701..507946	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
BKMNNEJI_RS02750	507915..508280	-	366	WP_001128433.1	hypothetical protein	Antitoxin
BKMNNEJI_RS02755	508335..508550	+	216	WP_001097552.1	hypothetical protein	-
BKMNNEJI_RS02760	508575..508838	+	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
BKMNNEJI_RS02765	508851..509012	+	162	WP_001285954.1	DUF1270 domain-containing protein	-
BKMNNEJI_RS02770	509091..509414	+	324	WP_000175000.1	hypothetical protein	-
BKMNNEJI_RS02775	509429..509791	+	363	WP_000985986.1	hypothetical protein	-
BKMNNEJI_RS02780	509788..510954	+	1167	WP_000762547.1	DUF2800 domain-containing protein	-
BKMNNEJI_RS02785	510981..511538	+	558	WP_031766091.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T289410 WP_001025401.1 NZ_LR822061:507701-507946 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 366 bp

>AT289410 NZ_LR822061:c508280-507915 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTTAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin