Detailed information of TA system TA289405

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 18786..19124
• Replicon: chromosome
• Accession: NZ_LR822061
• Organism: Staphylococcus aureus isolate HU-14

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: BKMNNEJI_RS00100
• Protein ID: WP_011447039.1
• Coordinates: 18786..18962 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	18950..19124 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BKMNNEJI_RS00080	14021..17806	+	3786	WP_000582179.1	hypothetical protein	-
BKMNNEJI_RS00085	17796..17948	+	153	WP_001153681.1	hypothetical protein	-
BKMNNEJI_RS00090	17995..18282	+	288	WP_001040261.1	hypothetical protein	-
BKMNNEJI_RS00095	18340..18636	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
BKMNNEJI_RS00100	18786..18962	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	18950..19124	-	175	-	-	Antitoxin
BKMNNEJI_RS00110	19174..19428	+	255	WP_000611512.1	phage holin	-
BKMNNEJI_RS00115	19440..20195	+	756	WP_000861038.1	CHAP domain-containing protein	-
BKMNNEJI_RS00120	20386..20877	+	492	WP_031879503.1	staphylokinase	-
BKMNNEJI_RS00125	21527..21862	+	336	Protein_24	SH3 domain-containing protein	-
BKMNNEJI_RS00130	21957..22406	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
BKMNNEJI_RS00135	22533..23705	+	1173	WP_000195429.1	IS256-like element IS256 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sak / chp / scn	1..24772	24771
	-	flank	IS/Tn	-	-	22533..23705	1172

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T289405 WP_011447039.1 NZ_LR822061:18786-18962 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

Antitoxin

Nucleotide

• Length: 175 bp

>AT289405 NZ_LR822061:c19124-18950 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin