Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2506742..2507259 Replicon chromosome
Accession NZ_LR822060
Organism Staphylococcus aureus isolate P3.1

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3A3ATA4
Locus tag LJDFIFNA_RS12470 Protein ID WP_000113265.1
Coordinates 2506993..2507259 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag LJDFIFNA_RS12465 Protein ID WP_000584499.1
Coordinates 2506742..2506993 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJDFIFNA_RS12435 2502439..2503158 + 720 WP_000479576.1 amino acid ABC transporter permease -
LJDFIFNA_RS12440 2503155..2503886 + 732 WP_000615456.1 amino acid ABC transporter ATP-binding protein -
LJDFIFNA_RS12445 2503983..2505233 - 1251 WP_001012225.1 FemA/FemB family glycyltransferase FmhA -
LJDFIFNA_RS12450 2505489..2505851 + 363 WP_000819843.1 DUF4467 domain-containing protein -
LJDFIFNA_RS12455 2505870..2506469 + 600 WP_000162810.1 DsbA family protein -
LJDFIFNA_RS12460 2506476..2506577 + 102 Protein_2423 hypothetical protein -
LJDFIFNA_RS12465 2506742..2506993 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LJDFIFNA_RS12470 2506993..2507259 + 267 WP_000113265.1 Txe/YoeB family addiction module toxin Toxin
LJDFIFNA_RS12475 2507294..2507365 + 72 Protein_2426 hypothetical protein -
LJDFIFNA_RS12480 2507554..2509101 + 1548 WP_000727772.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
LJDFIFNA_RS12485 2509287..2509754 + 468 WP_000153347.1 SRPBCC domain-containing protein -
LJDFIFNA_RS12490 2509838..2510020 + 183 WP_000230292.1 hypothetical protein -
LJDFIFNA_RS12495 2510237..2511061 + 825 WP_000572038.1 formate/nitrite transporter family protein -
LJDFIFNA_RS12500 2511295..2511831 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.0573

>T289397 WP_000113265.1 NZ_LR822060:2506993-2507259 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT289397 WP_000584499.1 NZ_LR822060:2506742-2506993 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BWF

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References