Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1154598..1155243 Replicon chromosome
Accession NC_020260
Organism Cronobacter sakazakii SP291

Toxin (Protein)


Gene name higB Uniprot ID A0A6L3QTA3
Locus tag CSSP291_RS05475 Protein ID WP_004388208.1
Coordinates 1154598..1154960 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A6L3TU83
Locus tag CSSP291_RS05480 Protein ID WP_004388209.1
Coordinates 1154947..1155243 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSSP291_RS05465 1149998..1153120 - 3123 WP_004388206.1 MdtB/MuxB family multidrug efflux RND transporter permease subunit -
CSSP291_RS05470 1153120..1154367 - 1248 WP_004388207.1 MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit -
CSSP291_RS05475 1154598..1154960 + 363 WP_004388208.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CSSP291_RS05480 1154947..1155243 + 297 WP_004388209.1 XRE family transcriptional regulator Antitoxin
CSSP291_RS05485 1155253..1156605 - 1353 WP_004388210.1 molecular chaperone -
CSSP291_RS05490 1156741..1157589 + 849 WP_015386509.1 DNA-3-methyladenine glycosylase 2 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-86)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 14197.07 Da        Isoelectric Point: 8.0154

>T28939 WP_004388208.1 NC_020260:1154598-1154960 [Cronobacter sakazakii SP291]
MAWTVIFTDRFNDWYQQQPEGLQDRIAALLWNLRYSGPLVGRPLVDTVKGSRYPNLKELRVQYGGEPWRVFFAFDAERQA
VVLCAGNKRSQKHFYDALIRQAEEEFFLHVQAMERRNENS

Download         Length: 363 bp

>T28939 NC_020260:1154598-1154960 [Cronobacter sakazakii SP291]
ATGGCATGGACGGTAATTTTTACCGATCGTTTTAACGACTGGTATCAGCAGCAGCCCGAAGGATTACAGGATCGTATCGC
CGCGCTCTTATGGAACTTACGTTATTCCGGCCCGCTTGTCGGACGCCCGCTGGTCGATACGGTGAAAGGTTCGCGTTATC
CCAACCTGAAAGAGCTACGTGTGCAGTATGGCGGTGAGCCCTGGCGCGTCTTTTTTGCGTTTGACGCTGAACGTCAGGCC
GTTGTGCTCTGCGCAGGCAATAAACGAAGCCAGAAACATTTTTATGACGCCTTAATCAGGCAGGCTGAAGAAGAATTCTT
CCTGCATGTGCAAGCGATGGAGAGACGAAATGAAAACTCTTGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10837.75 Da        Isoelectric Point: 5.8787

>AT28939 WP_004388209.1 NC_020260:1154947-1155243 [Cronobacter sakazakii SP291]
MKTLDDVMAGFSPERQAEILRMADEIALEHGLPRIREARAFSQQQLAEIMGVTQPAIAAIEQRGKEIKLLTLKRYVEALG
GKLSLLIELPEGSKVIPV

Download         Length: 297 bp

>AT28939 NC_020260:1154947-1155243 [Cronobacter sakazakii SP291]
ATGAAAACTCTTGATGACGTAATGGCGGGCTTTTCCCCGGAACGGCAGGCAGAAATCCTGCGCATGGCAGACGAAATTGC
GCTGGAGCACGGCCTGCCGCGCATTCGCGAAGCGCGGGCGTTTTCGCAGCAGCAGCTGGCGGAGATAATGGGCGTGACGC
AGCCCGCTATCGCCGCCATTGAGCAGCGCGGTAAGGAGATTAAACTGCTGACGCTCAAGCGCTACGTCGAAGCGCTGGGC
GGCAAGCTCTCTTTACTGATAGAACTGCCCGAAGGCAGCAAAGTGATCCCCGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L3QTA3

Antitoxin

Source ID Structure
AlphaFold DB A0A6L3TU83

References