Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-couple_hipB
Location 674043..674691 Replicon chromosome
Accession NZ_LR822035
Organism Streptococcus thermophilus isolate STH_CIRM_1051

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag H1X38_RS03570 Protein ID WP_014727406.1
Coordinates 674043..674408 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID J7TXL7
Locus tag H1X38_RS03575 Protein ID WP_002890617.1
Coordinates 674398..674691 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1X38_RS03555 670550..671695 + 1146 WP_014727403.1 abortive infection protein -
H1X38_RS03560 671857..672576 + 720 WP_014727404.1 hypothetical protein -
H1X38_RS03565 672628..673878 + 1251 WP_014727405.1 restriction endonuclease subunit S -
H1X38_RS03570 674043..674408 + 366 WP_014727406.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H1X38_RS03575 674398..674691 + 294 WP_002890617.1 helix-turn-helix transcriptional regulator Antitoxin
H1X38_RS03580 674713..676314 + 1602 WP_041829288.1 type I restriction-modification system subunit M -
H1X38_RS03585 676392..676811 + 420 Protein_648 PD-(D/E)XK nuclease family transposase -
H1X38_RS03590 676912..677862 + 951 Protein_649 DNA/RNA non-specific endonuclease -
H1X38_RS03595 678062..678622 + 561 WP_014621411.1 LemA family protein -
H1X38_RS03600 678624..679523 + 900 WP_014621412.1 zinc metalloprotease HtpX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(36-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-88)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 14511.65 Da        Isoelectric Point: 9.3397

>T289384 WP_014727406.1 NZ_LR822035:674043-674408 [Streptococcus thermophilus]
VHAIYFYKDKQGNQPVLDYMRELARHDSKDSRIKLNKLNDYIELLSQHGTCAGQPYIKHLDAEIWELRPLRDRILFVAWL
DGSFVLLHHFVKKTQKTPRREIEKAKRELQDLKERGLRDEE

Download         Length: 366 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10778.52 Da        Isoelectric Point: 5.8962

>AT289384 WP_002890617.1 NZ_LR822035:674398-674691 [Streptococcus thermophilus]
MKNSAIGSNWKDVRAELFTKEEILESDLRVAIMTELIEARHEKGFSQKKLEELSGVSQPVIARMETGKTSPQLDTVLKVL
ASLGKTLAVVPLEQEKL

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB J7TXL7

References