Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1098976..1099623 Replicon chromosome
Accession NC_020260
Organism Cronobacter sakazakii SP291

Toxin (Protein)


Gene name higB Uniprot ID A0A2S9UA56
Locus tag CSSP291_RS05240 Protein ID WP_004387788.1
Coordinates 1098976..1099323 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID V5TYW5
Locus tag CSSP291_RS05245 Protein ID WP_007776551.1
Coordinates 1099324..1099623 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSSP291_RS05210 1094268..1095278 + 1011 WP_004387466.1 galactose/methyl galactoside ABC transporter permease MglC -
CSSP291_RS05220 1095778..1096491 - 714 WP_004387784.1 outer membrane permeability protein SanA -
CSSP291_RS05225 1096616..1097500 - 885 WP_004387785.1 cytidine deaminase -
CSSP291_RS05230 1097630..1098325 - 696 WP_004387786.1 CidB/LrgB family autolysis modulator -
CSSP291_RS05235 1098322..1098723 - 402 WP_004387787.1 CidA/LrgA family protein -
CSSP291_RS05240 1098976..1099323 + 348 WP_004387788.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CSSP291_RS05245 1099324..1099623 + 300 WP_007776551.1 XRE family transcriptional regulator Antitoxin
CSSP291_RS05250 1099694..1100626 + 933 WP_004387790.1 tRNA dihydrouridine(16) synthase DusC -
CSSP291_RS05255 1100629..1101552 - 924 WP_015386496.1 LysR family transcriptional regulator -
CSSP291_RS05260 1101625..1102584 + 960 WP_029464216.1 MBL fold metallo-hydrolase -
CSSP291_RS21430 1102621..1102704 - 84 WP_000691708.1 protein YohP -
CSSP291_RS05265 1102877..1103650 + 774 WP_004387792.1 SDR family oxidoreductase -
CSSP291_RS05270 1103647..1104213 - 567 WP_004387793.1 DedA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-83)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13457.72 Da        Isoelectric Point: 10.2057

>T28938 WP_004387788.1 NC_020260:1098976-1099323 [Cronobacter sakazakii SP291]
MWTIYLTHEFECWLARQPQPLQEDVLAALGLLKIKGPHLGRPYADTLKGSRHAGMKELRVQHAGRPIRAFYAFDPHRYAI
VLCAAQKKGDEKRFYRVMLRVADKLFSHYLNHREV

Download         Length: 348 bp

>T28938 NC_020260:1098976-1099323 [Cronobacter sakazakii SP291]
ATGTGGACTATTTACCTTACTCACGAGTTTGAGTGCTGGCTCGCGAGACAGCCGCAGCCGTTGCAGGAAGATGTGCTGGC
CGCGCTGGGGCTTTTGAAAATCAAAGGTCCGCACCTCGGGCGTCCGTATGCCGATACGCTCAAAGGCTCGCGTCACGCGG
GTATGAAGGAATTACGGGTTCAGCACGCCGGGCGGCCCATACGCGCCTTTTACGCTTTTGATCCGCACCGTTATGCGATT
GTGCTGTGCGCGGCACAGAAAAAGGGGGATGAAAAGCGGTTTTACCGGGTCATGCTGCGCGTCGCTGACAAACTGTTTAG
CCACTATCTGAACCACCGGGAGGTATAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11035.67 Da        Isoelectric Point: 5.1667

>AT28938 WP_007776551.1 NC_020260:1099324-1099623 [Cronobacter sakazakii SP291]
MKTFDEVLAAQTPEARARIEEKTAQLLLETHLYALREALSVSQTEMARQMGIAQPSVAAIEQRGNEMKISTLKRYVEALG
GTVRLDVELPDGQRFGFTL

Download         Length: 300 bp

>AT28938 NC_020260:1099324-1099623 [Cronobacter sakazakii SP291]
ATGAAGACGTTTGATGAAGTGCTGGCGGCGCAGACCCCGGAGGCCCGCGCGCGTATCGAAGAGAAAACGGCGCAGCTGCT
GCTGGAAACCCATCTGTATGCGCTGCGCGAGGCGCTCAGCGTGTCGCAAACCGAGATGGCGCGCCAGATGGGTATCGCCC
AGCCGTCGGTCGCGGCTATCGAACAGCGCGGCAACGAGATGAAAATCTCAACGCTTAAGCGCTATGTCGAAGCCCTGGGC
GGCACGGTGCGACTGGATGTCGAGCTGCCGGACGGCCAACGTTTCGGTTTTACGCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S9UA56

Antitoxin

Source ID Structure
AlphaFold DB A0A2S9UA72

References