Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 862040..862815 Replicon chromosome
Accession NZ_LR792628
Organism Klebsiella pneumoniae isolate SB5881

Toxin (Protein)


Gene name TacT2 Uniprot ID W9B2R2
Locus tag HU711_RS04250 Protein ID WP_046042357.1
Coordinates 862330..862815 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag HU711_RS04245 Protein ID WP_004150912.1
Coordinates 862040..862333 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HU711_RS04225 857248..857850 - 603 WP_004174410.1 short chain dehydrogenase -
HU711_RS04230 857948..858859 + 912 WP_021314148.1 LysR family transcriptional regulator -
HU711_RS04235 858860..860008 - 1149 WP_016531357.1 PLP-dependent aspartate aminotransferase family protein -
HU711_RS04240 860019..861395 - 1377 WP_004174417.1 pyridoxal-phosphate dependent enzyme -
HU711_RS04245 862040..862333 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
HU711_RS04250 862330..862815 + 486 WP_046042357.1 GNAT family N-acetyltransferase Toxin
HU711_RS04255 863519..864112 + 594 WP_004188553.1 hypothetical protein -
HU711_RS04260 864209..864425 + 217 Protein_827 transposase -
HU711_RS04270 864940..865653 - 714 WP_002916694.1 DUF554 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 864209..864361 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17611.64 Da        Isoelectric Point: 8.5144

>T289351 WP_046042357.1 NZ_LR792628:862330-862815 [Klebsiella pneumoniae]
MILAPESLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT289351 WP_004150912.1 NZ_LR792628:862040-862333 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W9B2R2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References