Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 499294..499940 Replicon chromosome
Accession NZ_LR792628
Organism Klebsiella pneumoniae isolate SB5881

Toxin (Protein)


Gene name higB Uniprot ID W9BBY1
Locus tag HU711_RS02325 Protein ID WP_016529833.1
Coordinates 499294..499641 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W9BB18
Locus tag HU711_RS02330 Protein ID WP_016529832.1
Coordinates 499641..499940 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HU711_RS02315 495220..496653 + 1434 WP_002920564.1 glycogen synthase GlgA -
HU711_RS02320 496671..499118 + 2448 WP_174893331.1 glycogen phosphorylase -
HU711_RS02325 499294..499641 + 348 WP_016529833.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HU711_RS02330 499641..499940 + 300 WP_016529832.1 helix-turn-helix domain-containing protein Antitoxin
HU711_RS02335 500003..501511 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
HU711_RS02340 501716..502045 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
HU711_RS02345 502096..502926 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
HU711_RS02350 502976..503734 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13549.56 Da        Isoelectric Point: 5.6749

>T289350 WP_016529833.1 NZ_LR792628:499294-499641 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.63 Da        Isoelectric Point: 10.4041

>AT289350 WP_016529832.1 NZ_LR792628:499641-499940 [Klebsiella pneumoniae]
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQTDNAPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W9BBY1

Antitoxin

Source ID Structure
AlphaFold DB W9BB18

References