Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3987800..3988341 Replicon chromosome
Accession NZ_LR782232
Organism Escherichia coli isolate SC467

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag HV361_RS19030 Protein ID WP_000615976.1
Coordinates 3988063..3988341 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag HV361_RS19025 Protein ID WP_000729704.1
Coordinates 3987800..3988060 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV361_RS19000 3982836..3983975 + 1140 WP_000785662.1 flagellar type III secretion system protein FlhB -
HV361_RS19005 3983959..3986052 + 2094 WP_001140806.1 flagellar biosynthesis protein FlhA -
HV361_RS19010 3986157..3986435 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
HV361_RS19015 3986428..3986784 + 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
HV361_RS19020 3986841..3987614 - 774 WP_000543899.1 C40 family peptidase -
HV361_RS19025 3987800..3988060 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
HV361_RS19030 3988063..3988341 + 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
HV361_RS19035 3988497..3989237 + 741 WP_001225679.1 murein L,D-transpeptidase -
HV361_RS19040 3989208..3989975 - 768 WP_000333380.1 class II glutamine amidotransferase -
HV361_RS19045 3990181..3990759 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T289343 WP_000615976.1 NZ_LR782232:3988063-3988341 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT289343 WP_000729704.1 NZ_LR782232:3987800-3988060 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References