Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2137601..2138103 Replicon chromosome
Accession NZ_LR782232
Organism Escherichia coli isolate SC467

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag HV361_RS10085 Protein ID WP_000767829.1
Coordinates 2137849..2138103 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag HV361_RS10080 Protein ID WP_001259255.1
Coordinates 2137601..2137852 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV361_RS10055 2132779..2133846 - 1068 WP_000080102.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
HV361_RS10060 2133846..2134916 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
HV361_RS10065 2134913..2136217 - 1305 WP_038994445.1 histidinol dehydrogenase -
HV361_RS10070 2136223..2137122 - 900 WP_000131777.1 ATP phosphoribosyltransferase -
HV361_RS10075 2137268..2137318 - 51 WP_001364200.1 his operon leader peptide -
HV361_RS10080 2137601..2137852 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
HV361_RS10085 2137849..2138103 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
HV361_RS10090 2138186..2139010 + 825 WP_000754758.1 SDR family oxidoreductase -
HV361_RS10095 2139056..2139985 + 930 WP_000803351.1 LysR family transcriptional regulator -
HV361_RS10100 2140200..2140262 + 63 WP_010723108.1 membrane protein YoeI -
HV361_RS10105 2140252..2141610 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
HV361_RS10110 2141789..2142847 + 1059 WP_000492346.1 transport protein YeeE -
HV361_RS10115 2142861..2143088 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T289335 WP_000767829.1 NZ_LR782232:2137849-2138103 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT289335 WP_001259255.1 NZ_LR782232:2137601-2137852 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References