Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 4138698..4139304 Replicon chromosome
Accession NZ_LR778301
Organism Denitratisoma oestradiolicum strain DSM 16959

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag DENOEST_RS18895 Protein ID WP_145770282.1
Coordinates 4138698..4139021 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DENOEST_RS18900 Protein ID WP_145770281.1
Coordinates 4139014..4139304 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DENOEST_RS18865 4133728..4134342 + 615 WP_197970664.1 PD-(D/E)XK nuclease family protein -
DENOEST_RS18870 4134342..4134821 + 480 WP_145770287.1 hypothetical protein -
DENOEST_RS20000 4134814..4135677 + 864 WP_197970665.1 hypothetical protein -
DENOEST_RS18875 4135595..4137139 + 1545 WP_197970666.1 hypothetical protein -
DENOEST_RS18880 4137277..4137750 + 474 WP_145770285.1 hypothetical protein -
DENOEST_RS18885 4137747..4138109 + 363 WP_183148178.1 hypothetical protein -
DENOEST_RS18890 4138106..4138690 + 585 WP_145770283.1 hypothetical protein -
DENOEST_RS18895 4138698..4139021 + 324 WP_145770282.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DENOEST_RS18900 4139014..4139304 + 291 WP_145770281.1 helix-turn-helix domain-containing protein Antitoxin
DENOEST_RS18905 4139464..4139667 + 204 WP_145770280.1 hypothetical protein -
DENOEST_RS18910 4139654..4139878 + 225 WP_183148293.1 hypothetical protein -
DENOEST_RS18915 4139841..4140230 + 390 WP_183148294.1 hypothetical protein -
DENOEST_RS18920 4140427..4140987 + 561 WP_145770278.1 hypothetical protein -
DENOEST_RS20005 4141001..4141720 + 720 WP_197970667.1 ParB N-terminal domain-containing protein -
DENOEST_RS20010 4141693..4142406 + 714 WP_197970668.1 site-specific DNA-methyltransferase -
DENOEST_RS18930 4142387..4143730 + 1344 WP_145770276.1 site-specific DNA-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4132165..4167650 35485


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(9-99)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-86)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12035.95 Da        Isoelectric Point: 7.8165

>T289327 WP_145770282.1 NZ_LR778301:4138698-4139021 [Denitratisoma oestradiolicum]
MVFVELPIFVRCAAELFSDEDMAELQNTLLENPAAGDLIPGGRGLRKLRVPLPGRGKRGGARVIYYHWVSKAQCYLIYAY
AKNVSANLTPDQLRRLAEVMQAEIRDE

Download         Length: 324 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10793.40 Da        Isoelectric Point: 10.6485

>AT289327 WP_145770281.1 NZ_LR778301:4139014-4139304 [Denitratisoma oestradiolicum]
MNDKQFDELLSSVRDMGRHMRGEAVAGVRVQEFPEPDVKAIRERTGLSQSRFAYLIGVKPKTLQNWEQRRVRPAGPARAL
LKIVEANPDALSAIHA

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References