Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 24948..25554 Replicon chromosome
Accession NZ_LR778301
Organism Denitratisoma oestradiolicum strain DSM 16959

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag DENOEST_RS00175 Protein ID WP_145770282.1
Coordinates 24948..25271 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DENOEST_RS00180 Protein ID WP_145770281.1
Coordinates 25264..25554 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DENOEST_RS00150 20620..21060 + 441 WP_183148177.1 hypothetical protein -
DENOEST_RS19850 21064..22197 + 1134 WP_197970458.1 hypothetical protein -
DENOEST_RS19855 22184..23389 + 1206 WP_197970459.1 hypothetical protein -
DENOEST_RS00160 23527..24000 + 474 WP_145770285.1 hypothetical protein -
DENOEST_RS00165 23997..24359 + 363 WP_183148178.1 hypothetical protein -
DENOEST_RS00170 24356..24940 + 585 WP_145770283.1 hypothetical protein -
DENOEST_RS00175 24948..25271 + 324 WP_145770282.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DENOEST_RS00180 25264..25554 + 291 WP_145770281.1 helix-turn-helix domain-containing protein Antitoxin
DENOEST_RS00185 25714..25917 + 204 WP_145770280.1 hypothetical protein -
DENOEST_RS00190 25904..26482 + 579 WP_145770279.1 hypothetical protein -
DENOEST_RS00195 26678..27238 + 561 WP_145770278.1 hypothetical protein -
DENOEST_RS00200 27253..28659 + 1407 WP_197970675.1 site-specific DNA-methyltransferase -
DENOEST_RS00205 28640..29773 + 1134 WP_197970460.1 ParB N-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 18441..67575 49134


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(9-99)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-86)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12035.95 Da        Isoelectric Point: 7.8165

>T289323 WP_145770282.1 NZ_LR778301:24948-25271 [Denitratisoma oestradiolicum]
MVFVELPIFVRCAAELFSDEDMAELQNTLLENPAAGDLIPGGRGLRKLRVPLPGRGKRGGARVIYYHWVSKAQCYLIYAY
AKNVSANLTPDQLRRLAEVMQAEIRDE

Download         Length: 324 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10793.40 Da        Isoelectric Point: 10.6485

>AT289323 WP_145770281.1 NZ_LR778301:25264-25554 [Denitratisoma oestradiolicum]
MNDKQFDELLSSVRDMGRHMRGEAVAGVRVQEFPEPDVKAIRERTGLSQSRFAYLIGVKPKTLQNWEQRRVRPAGPARAL
LKIVEANPDALSAIHA

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References