Detailed information of TA system TA289294

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 3680466..3680688
• Replicon: chromosome
• Accession: NZ_LR778152
• Organism: Escherichia coli isolate SC477

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: H1D09_RS17805
• Protein ID: WP_001295224.1
• Coordinates: 3680581..3680688 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	3680466..3680532 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H1D09_RS17775	3675470..3676483	+	1014	WP_053898372.1	dipeptide ABC transporter ATP-binding subunit DppF	-
H1D09_RS17780	3676708..3677031	+	324	WP_000563102.1	helix-turn-helix transcriptional regulator	-
H1D09_RS17785	3677016..3677327	+	312	WP_001490601.1	HipA N-terminal domain-containing protein	-
H1D09_RS17790	3677327..3678334	+	1008	WP_024225716.1	HipA domain-containing protein	-
H1D09_RS17795	3678351..3679622	-	1272	WP_001312176.1	amino acid permease	-
H1D09_RS17800	3680098..3680205	+	108	WP_000170747.1	type I toxin-antitoxin system toxin Ldr family protein	-
-	3680466..3680532	-	67	-	-	Antitoxin
H1D09_RS17805	3680581..3680688	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
H1D09_RS17810	3680774..3682453	-	1680	WP_000191568.1	cellulose biosynthesis protein BcsG	-
H1D09_RS17815	3682450..3682641	-	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
H1D09_RS17820	3682638..3684209	-	1572	WP_175058660.1	cellulose biosynthesis protein BcsE	-
H1D09_RS17825	3684482..3684670	+	189	WP_001063314.1	YhjR family protein	-
H1D09_RS17830	3684682..3685434	+	753	WP_175058661.1	cellulose biosynthesis protein BcsQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T289294 WP_001295224.1 NZ_LR778152:3680581-3680688 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

Antitoxin

Nucleotide

• Length: 67 bp

>AT289294 NZ_LR778152:c3680532-3680466 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin