289293

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 3677016..3678334 Replicon chromosome
Accession NZ_LR778152
Organism Escherichia coli isolate SC477

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag H1D09_RS17790 Protein ID WP_024225716.1
Coordinates 3677327..3678334 (+) Length 336 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID A0A2A7M399
Locus tag H1D09_RS17785 Protein ID WP_001490601.1
Coordinates 3677016..3677327 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1D09_RS17760 3672548..3673567 + 1020 WP_000938855.1 dipeptide ABC transporter permease DppB -
H1D09_RS17765 3673577..3674479 + 903 WP_000084677.1 dipeptide ABC transporter permease DppC -
H1D09_RS17770 3674490..3675473 + 984 WP_112886706.1 dipeptide ABC transporter ATP-binding protein -
H1D09_RS17775 3675470..3676483 + 1014 WP_053898372.1 dipeptide ABC transporter ATP-binding subunit DppF -
H1D09_RS17780 3676708..3677031 + 324 WP_000563102.1 helix-turn-helix transcriptional regulator -
H1D09_RS17785 3677016..3677327 + 312 WP_001490601.1 HipA N-terminal domain-containing protein Antitoxin
H1D09_RS17790 3677327..3678334 + 1008 WP_024225716.1 HipA domain-containing protein Toxin
H1D09_RS17795 3678351..3679622 - 1272 WP_001312176.1 amino acid permease -
H1D09_RS17800 3680098..3680205 + 108 WP_000170747.1 type I toxin-antitoxin system toxin Ldr family protein -
H1D09_RS17805 3680581..3680688 + 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
H1D09_RS17810 3680774..3682453 - 1680 WP_000191568.1 cellulose biosynthesis protein BcsG -
H1D09_RS17815 3682450..3682641 - 192 WP_000988308.1 cellulose biosynthesis protein BcsF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-302)

Antitoxin

HipA, N-terminal subdomain 1

(6-98)


Sequences

Toxin        


Download         Length: 336 a.a.        Molecular weight: 38384.63 Da        Isoelectric Point: 5.6166

>T289293 WP_024225716.1 NZ_LR778152:3677327-3678334 [Escherichia coli]
MANCRILLTPLNERDEQRGYSTQGLKRLSGTAKLTPRLGFTRTQFVQELPRQQKGMSISGYQPKLQLVLNEGEFRVVDHQ
GNFILKPSPADFPGLAENEHATMTLMSRLGFDVSVHGLLSFAPQSEEELEYAFVIRRYDRDYKGLPVHQEQLDGAMQITD
KYGKTGNDNEQYVSYETLARFLVAHVNDNIAFKIDLFRRIVYAWLLGNNDMHLRNFGLVYSDGLTPTLAPVYDFVSVAPY
PEYFYSNYLALPLLTREEGGRELAPGFHSDYGEYIGQDFLLLGESMGLAPRLLEKLFQDIRKENAIVMETYEQSFMTQDH
IQAVLQCYRHRLGLL

Download         Length: 1008 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11822.40 Da        Isoelectric Point: 6.0609

>AT289293 WP_001490601.1 NZ_LR778152:3677016-3677327 [Escherichia coli]
MHRRVKVLLYGQVVGELSQNDSGFLFQYAQDYHGPAISISLPVAQRQFPSETLHPYFASLAPEGWLRQRYSQIQHRDEND
LLGMLIDNGKNLLGAIQILPWEE

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2A7M399

References