Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 3919775..3920377 Replicon chromosome
Accession NZ_LR778151
Organism Escherichia coli isolate SC476

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag H1C97_RS18900 Protein ID WP_000897305.1
Coordinates 3919775..3920086 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag H1C97_RS18905 Protein ID WP_000356397.1
Coordinates 3920087..3920377 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1C97_RS18870 3914805..3915590 + 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -
H1C97_RS18875 3915689..3916288 + 600 WP_001295269.1 glucose-1-phosphatase -
H1C97_RS18880 3916282..3917154 + 873 WP_000920762.1 virulence factor BrkB family protein -
H1C97_RS18885 3917151..3917588 + 438 WP_000560983.1 D-tyrosyl-tRNA(Tyr) deacylase -
H1C97_RS18890 3917633..3918574 + 942 WP_001343389.1 fatty acid biosynthesis protein FabY -
H1C97_RS18895 3918638..3919546 - 909 WP_001162704.1 alpha/beta hydrolase -
H1C97_RS18900 3919775..3920086 + 312 WP_000897305.1 hypothetical protein Toxin
H1C97_RS18905 3920087..3920377 + 291 WP_000356397.1 helix-turn-helix domain-containing protein Antitoxin
H1C97_RS18910 3920982..3921200 + 219 WP_001297075.1 ribbon-helix-helix domain-containing protein -
H1C97_RS18915 3921419..3921661 + 243 WP_001086388.1 hypothetical protein -
H1C97_RS18920 3921991..3922920 - 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
H1C97_RS18925 3922917..3923552 - 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
H1C97_RS18930 3923549..3924451 - 903 WP_000331377.1 formate dehydrogenase O subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T289276 WP_000897305.1 NZ_LR778151:3919775-3920086 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT289276 WP_000356397.1 NZ_LR778151:3920087-3920377 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References