Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3110473..3111272 Replicon chromosome
Accession NZ_LR778151
Organism Escherichia coli isolate SC476

Toxin (Protein)


Gene name yhaV Uniprot ID F4VJD3
Locus tag H1C97_RS14995 Protein ID WP_000347266.1
Coordinates 3110808..3111272 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag H1C97_RS14990 Protein ID WP_001307405.1
Coordinates 3110473..3110808 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1C97_RS14975 3106258..3107028 - 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -
H1C97_RS14980 3107044..3108378 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
H1C97_RS14985 3108753..3110324 + 1572 WP_001273741.1 galactarate dehydratase -
H1C97_RS14990 3110473..3110808 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
H1C97_RS14995 3110808..3111272 + 465 WP_000347266.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
H1C97_RS15000 3111327..3112136 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
H1C97_RS15005 3112385..3113665 + 1281 WP_000681921.1 tagatose-bisphosphate aldolase subunit KbaZ -
H1C97_RS15010 3113688..3114161 + 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
H1C97_RS15015 3114172..3114951 + 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
H1C97_RS15020 3114941..3115819 + 879 WP_001298758.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
H1C97_RS15025 3115837..3116271 + 435 WP_000948824.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3099817..3111272 11455


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17841.18 Da        Isoelectric Point: 9.4947

>T289274 WP_000347266.1 NZ_LR778151:3110808-3111272 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRFFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT289274 WP_001307405.1 NZ_LR778151:3110473-3110808 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A836NGD2

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References