289270

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1933354..1933856 Replicon chromosome
Accession NZ_LR778151
Organism Escherichia coli isolate SC476

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag H1C97_RS09490 Protein ID WP_000767829.1
Coordinates 1933354..1933608 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag H1C97_RS09495 Protein ID WP_001259255.1
Coordinates 1933605..1933856 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1C97_RS09460 1928369..1928596 - 228 WP_000985273.1 sulfurtransferase TusA family protein -
H1C97_RS09465 1928610..1929668 - 1059 WP_000492340.1 transport protein YeeE -
H1C97_RS09470 1929847..1931205 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
H1C97_RS09475 1931195..1931257 - 63 WP_010723108.1 membrane protein YoeI -
H1C97_RS09480 1931472..1932401 - 930 WP_000803351.1 LysR family transcriptional regulator -
H1C97_RS09485 1932447..1933271 - 825 WP_000754737.1 SDR family oxidoreductase -
H1C97_RS09490 1933354..1933608 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
H1C97_RS09495 1933605..1933856 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
H1C97_RS09500 1934139..1934189 + 51 WP_001364200.1 his operon leader peptide -
H1C97_RS09505 1934335..1935234 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
H1C97_RS09510 1935240..1936545 + 1306 Protein_1852 histidinol dehydrogenase -
H1C97_RS09515 1936542..1937612 + 1071 WP_000108967.1 histidinol-phosphate transaminase -
H1C97_RS09520 1937612..1938679 + 1068 WP_044687408.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T289270 WP_000767829.1 NZ_LR778151:c1933608-1933354 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT289270 WP_001259255.1 NZ_LR778151:c1933856-1933605 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References