Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1933354..1933856 Replicon chromosome
Accession NZ_LR778151
Organism Escherichia coli isolate SC476

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag H1C97_RS09490 Protein ID WP_000767829.1
Coordinates 1933354..1933608 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag H1C97_RS09495 Protein ID WP_001259255.1
Coordinates 1933605..1933856 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1C97_RS09460 1928369..1928596 - 228 WP_000985273.1 sulfurtransferase TusA family protein -
H1C97_RS09465 1928610..1929668 - 1059 WP_000492340.1 transport protein YeeE -
H1C97_RS09470 1929847..1931205 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
H1C97_RS09475 1931195..1931257 - 63 WP_010723108.1 membrane protein YoeI -
H1C97_RS09480 1931472..1932401 - 930 WP_000803351.1 LysR family transcriptional regulator -
H1C97_RS09485 1932447..1933271 - 825 WP_000754737.1 SDR family oxidoreductase -
H1C97_RS09490 1933354..1933608 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
H1C97_RS09495 1933605..1933856 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
H1C97_RS09500 1934139..1934189 + 51 WP_001364200.1 his operon leader peptide -
H1C97_RS09505 1934335..1935234 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
H1C97_RS09510 1935240..1936545 + 1306 Protein_1852 histidinol dehydrogenase -
H1C97_RS09515 1936542..1937612 + 1071 WP_000108967.1 histidinol-phosphate transaminase -
H1C97_RS09520 1937612..1938679 + 1068 WP_044687408.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T289270 WP_000767829.1 NZ_LR778151:c1933608-1933354 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT289270 WP_001259255.1 NZ_LR778151:c1933856-1933605 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References