Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 52560..53101 Replicon chromosome
Accession NZ_LR778151
Organism Escherichia coli isolate SC476

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag H1C97_RS00235 Protein ID WP_000615976.1
Coordinates 52560..52838 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag H1C97_RS00240 Protein ID WP_000729704.1
Coordinates 52841..53101 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1C97_RS00220 50142..50720 + 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -
H1C97_RS00225 50926..51693 + 768 WP_000333380.1 class II glutamine amidotransferase -
H1C97_RS00230 51664..52404 - 741 WP_001225679.1 murein L,D-transpeptidase -
H1C97_RS00235 52560..52838 - 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
H1C97_RS00240 52841..53101 - 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
H1C97_RS00245 53287..54060 + 774 WP_000543899.1 C40 family peptidase -
H1C97_RS00250 54117..54473 - 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
H1C97_RS00255 54466..54744 - 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
H1C97_RS00260 54849..56561 - 1713 Protein_44 flagellar biosynthesis protein FlhA -
H1C97_RS00265 56533..57318 + 786 WP_063518482.1 putative lateral flagellar export/assembly protein LafU -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T289260 WP_000615976.1 NZ_LR778151:c52838-52560 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT289260 WP_000729704.1 NZ_LR778151:c53101-52841 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References